HER2阳性胃癌临床病理特征分析 |
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引用本文: | 江 慧,宋 纯,张桂荣. HER2阳性胃癌临床病理特征分析[J]. 中国肿瘤, 2014, 23(5): 421-425 |
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作者姓名: | 江 慧 宋 纯 张桂荣 |
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作者单位: | 辽宁省肿瘤医院,大连医科大学临床肿瘤学院;辽宁省肿瘤医院,大连医科大学临床肿瘤学院;辽宁省肿瘤医院,大连医科大学临床肿瘤学院 |
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基金项目: | 辽宁省医学高峰建设工程项目(2010077);辽宁省博士科研启动基金项目(20101059) |
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摘 要: | [目的]分析胃癌HER2阳性率,探讨HER2阳性胃癌临床病理特征。[方法]采用免疫组织化学法(IHC)检测HER2蛋白表达,采用荧光原位杂交(FISH)检测HER2基因扩增。[结果]110例胃癌组织HER2IHC阳性率为6.4%(7/110),FISH阳性率为14.5%(16/110)。排除IHC2+,IHC与FISH检测结果符合率为96%。HER2总体阳性率为10.9%。Lauren分型肠型胃癌HER2阳性率高于混合型和弥漫型(18.0%vs5.0%,P〈0.05)。WHO分型管状腺癌HER2阳性率高于其他类型(19.3%VS2.3%,P〈0.05),中、高分化胃癌HER2阳性率高于低分化胃癌(20.0%vs5.7%,P〈0.05)。HER2阳性率在不同年龄、性别、肿瘤部位、肿瘤大小、淋巴结转移和TNM分期胃癌中无统计学差异(P〉0.05)。[结论]胃癌HER2阳性与Lauren分型及wHO分型、分级有关。
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关 键 词: | 胃癌 HER2 免疫组织化学法 荧光原位杂交 |
收稿时间: | 2013-08-28 |
Clinicopathological Characteristics of HER2-positive Gastric Cancer |
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Affiliation: | JIANG Hui, SONG Chun, ZHANG Gui-rong, et al. (Liaoning Cancer Hospital & Institute,Dalian Medical University Clinical Oncology College, Shenyang 110042,China) |
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Abstract: | [Purposel To investigate the positive rate of HER2 in gastric cancer and the clinico- pathologic characteristics of HER2-positive gastric cancer. [Methodsl HER2 expression was de- tected by immunohistochemistry (IHC). HER2 gene amplification was analyzed by fluorescence in situ hybridization (FISH). [Results] In 110 cases of gastric cancer,positive rates of HER2 IHC and FISH testing were 6.4% (7/110) and 14.5% (16/110) respectively. A coincidence rate of 96% between IHC and FISH results was demonstrated when IHC2+ was excluded. The overall HER2 positive rate was 10.9%. Intestinal type gastric carcinomas by Lauren's classification showed sig- nificantly higher HER2 positive rate than that in mixed and diffuse types (18.0% vs 5.0% ,P〈0.05). Tubular adenocarcinoma by WHO classification revealed markedly higher HER2 positive rate than that in others(19.3% vs 2.3%,P〈0.05). HER2 positive rate in well and moderately differenti- ated gastric cancer was significantly higher than that in poorly differentiated type (20.0% vs 5.7%, P〈0.05). There was no statistical differences in HER2 positive rates in gastric cancer sub- groups stratified by age,gender,tumor location,tumor size,lymph node metastasis or TNM stages (P〉0.05). [ Conclusion ] HER2-positive is associated with Lauren classification and WHO classifi- cation/differentiation in gastric cancer. |
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Keywords: | gastric cancer HER2 immunohistochemistry fluorescence in situ hybridization |
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