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| 顺铂水溶液稳定性研究 | |
| 引用本文： | 唐星,何仲贵,于叶玲,毕殿洲,宁国涛,王兆红. 顺铂水溶液稳定性研究[J]. 沈阳药科大学学报, 2000, 17(6): 405-407 |
| 作者姓名： | 唐星 何仲贵 于叶玲 毕殿洲 宁国涛 王兆红 |
| 作者单位： | 1. 沈阳药科大学药学系沈阳 11015 2. 沈阳药科大学药学系，沈阳 110015 3. 黑龙江华星制药股份有限公司，合尔滨151100 |
| 摘 要： | 建立了高效液相色谱法 (HPLC)测定顺铂水溶液的稳定性 ,考察了pH值、氯化钠浓度、温度及光照对顺铂水溶液稳定性的影响 .由HPLC图谱表明 ,顺铂在不同 pH值水溶液中 ,产生不同的降解产物 ,说明其降解机制不同 .pH值在 4 0～ 6 0时 ,顺铂水溶液稳定性较好 ,氯化钠浓度在0 9%～ 1 5 %范围内顺铂较稳定 ,0 9%以下稳定性较差 ,顺铂水溶液对光十分敏感 . |
| 关 键 词： | 高效液相色谱 顺铂水溶液 稳定性 |
| 修稿时间： | 2000-04-14 |
A Study on the Stability of the Cisplatin Aqueous Solution |
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| Tang Xing,He Zhonggui,Yu Yeling,Bi Dianzhou,Ning Guotao,Wang Zhaohong. A Study on the Stability of the Cisplatin Aqueous Solution[J]. Journal of Shenyang Pharmaceutical University, 2000, 17(6): 405-407 | |
| Authors: | Tang Xing He Zhonggui Yu Yeling Bi Dianzhou Ning Guotao Wang Zhaohong |
| Affiliation: | Tang Xing,He Zhonggui,Yu Yeling,Bi Dianzhou,Ning Guotao,Wang ZhaohongDepartment of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110015 |
| Abstract: | The specific HPLC method was established for determining the stability of the cisplatin aqueous solution.The μ-Bondapark NH-2 was the stationary phase.The mobile phase was acetonitrile∶water∶95% ethanol(73∶12∶15).The effects of pH value,sodium chloride concentration,temperature and light on the stability of the cisplation solution were studied.The results showed that the discomposition mechanism of cisplatin aqueous solution was different at different conditions.At pH4 0～6 0.the cisplatin aqueous solution was more stable,but sensitive to light. |
| Keywords: | HPLC cisplatin aqueous solution stability |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |