膈下逐瘀汤合失笑散联合三阶梯止痛治疗气滞血瘀型肿瘤晚期癌痛随机平行对照研究

[目的]观察膈下逐瘀汤合失笑散联合三阶梯止痛治疗气滞血瘀型肿瘤晚期癌痛疗效。[方法]使用随机平行对照方法,将80例门诊患者按抽签方法随机分为两组,对照组40例三阶梯止痛,按疼痛程度顺序使用更强止痛剂,第一步非鸦片类,第二步弱鸦片类,第三步强鸦片类,辅助药物与止痛药物联合使用,治疗组40例膈下逐瘀汤合失笑散（蒲黄6g,五灵脂10g,乌药、桃仁、丹皮、赤芍、延胡、香附、红花各12g,田七10g,枳壳12g,徐长卿30g）,1剂/d,水煎300mL,早晚口服,西药治疗同对照组,连续治疗4周为1疗程。观测临床症状、疼痛程度、不良反应。连续治疗3疗程,判定疗效。[结果]治疗组CR14例,PR16例,MR7例,NR3例,总有效率92.50%。对照组CR10例,PR11例,MR13例,NR7例,总有效率82.50%。治疗组疗效优于对照组（P〈0.05）。[结论]膈下逐瘀汤合失笑散联合三阶梯止痛治疗气滞血瘀型肿瘤晚期癌痛,疗效满意,可推广应用。

Gexia Zhuyu Decoction Combined with Shixiaosan Combined Three Ladder Analgesic Treatment of Qi Stagnation and Blood Stasis Type Tumors in Advanced Cancer Patients Randomized Parallel Controlled Study

[Objective]To observe the Gexia Zhuyu Decoction Combined with Shixiaosan combined three ladder analgesic efficacy in the treatment of qi stagnation and blood stasis type advanced cancer pain.[Method]Using randomized controlled methods,80 patients were in the draw method were randomly divided into two groups,40 cases in the control group the three ladder acesodyne medication,according to the degree of pain in order to use stronger painkillers,the first step of non opioid,second weak opioids,third strong opioids,combined use of adjuvant drugs and analgesic drugs,the treatment group of 40 cases of phrenic Zhuyu Decoction Combined with Shixiaosan（Puhuang 6g,Wulingzhi 10g,Wuyao Taoren Danpi Chishao Yanhu Xiangfu Honghua Ge 12g,Tianqi 10g,Zhike 12g,Xu changqing 30g）,1 doses of /d,300mL oral decoction,sooner or later,the western medicine treatment control group,continuous treatment for 4 weeks as 1 course of treatment. Observation of clinical symptoms,adverse reaction. Continuous 3 courses of treatment,the curative effect.[Results]Group of CR14 patients,treatment of PR16 cases,MR7 cases,NR3 cases,the total efficiency of 92.50%. Control group CR10 cases,PR11 cases,MR13 cases,NR7 cases,the total efficiency of 82.50%.The efficacy of the treatment group than in control group（P 0.05）.[Conclusion]Gexia Zhuyu Decoction Combined with Shixiaosan combined three ladder analgesic treatment of qi stagnation and blood stasis type tumor cancer pain,curative effect satisfaction,can be applied.