射频消融治疗子宫肌瘤的安全性研究

目的 :探讨射频消融治疗子宫肌瘤的安全性。方法 :选择自愿接受射频消融治疗子宫肌瘤 2 4 8例 ,在B超监视和引导下将射频治疗刀经阴道宫颈置入病灶进行高频电治疗 ,其中 2 8例于治疗前和治疗后 6月同时行盆腔彩超检查子宫、卵巢血液供应 ,放射免疫检测卵巢、垂体激素水平。结果 :①治疗有效率为 97.2 % ,治愈率 6 6 .9% ,其中粘膜下肌瘤治疗效果最佳 ,有效率 10 0 % ,治愈率 88.9%。②子宫肌瘤患者子宫动脉血液供应比健康妇女丰富(P <0 .0 5 ) ,治疗后明显降低 ,但与健康妇女无明显差别 ,卵巢动脉血液供应、卵巢性激素、垂体促性腺激素水平治疗后与治疗前无明显变化 ,与健康妇女亦无明显差别 (P >0 .0 5 )。③全部治疗病例未发生严重并发症。结论 :射频消融治疗子宫肌瘤临床应用效果明显 ,治疗后不改变子宫、卵巢的血液供应 ,不影响垂体、卵巢的激素分泌 ,对子宫、卵巢、垂体功能无影响。射频消融治疗子宫肌瘤创伤小 ,无近、远期副作用 ,安全性高 ,值得推广应用

The Study of safety of the treatment of uterine myoma by means of radiofrequency ablation

Objective To probe into the safety of treatment of uterine myoma by means of radiofrequency ablation.Method We selected 248 cases voluntarily accepting uterine myoma treatment with radiofrquency ablation as our study objects.They were given highfrequency electrical treatment in the way of inserting the radiofrequency therapy knife through vagina and cervix into the focus of infection under the supervisor and guidance of B ultrasound.Before and after the treatment during the sixth month,among these cases,28 cases were given observation.The blood perfusion of uterus and ovary were observed by Pelvic color doppler ultrasonography, and the hormone of ovary and pituitary were measured by radioimmunoassay.Result ①The ratio of the effective treatment was 97.2%,and the ratio of the curability reached 66.9%,among which the treatment of submucous myoma had the best effectiveness-ratio of 100%, and the ratio of their curability reached 88.9%.②The uterine artery blood perfusion of uterine myoma is abundant than the normal's( P <0.05),they will decline obviously after treatment, but they have no obviously distinction with normal's.The blood perfusion of ovarian artery,ovarian hormone,pituitary gonadotropin have no obviously change before and after treatment, and they have no obviously distinction with normal's( P >0.05).③After radiofrequency ablation cases have no seriously complication.Conclusion The radiofrequency ablation treatment of the uterine myoma,the clinical effect is obvious good.It doesn't change the blood perfuision of uterus and ovary,the hormone excretion of ovary and pituitany.And it has no affect on the function of uterus, ovary and pituitany.It's acceptable, easy to operate,and deserves wide application.It's a new type of mini invasive technique.It is of great safety,and has no side-effect.