右半结肠癌与直肠癌的临床特征变化研究

目的近年来中国结直肠癌发病率明显上升, 其构成比和临床特点发生了显著变化。本文针对近15年哈尔滨医科大学附属肿瘤医院收治的右半结肠癌与直肠癌临床特点进行研究。方法 对1992年-2006年在哈尔滨医科大学附属肿瘤医院接受治疗的2552例右半结肠癌与直肠癌的临床病理特点, 以5年为一阶段进行回顾性分析, 所有病例均有病理确诊。结果 2002年-2006年段与1992年-1997年段比较, 右半结肠癌与直肠癌收治率每年分别同比增长6.7%和6.0%;发病平均年龄从53.1岁和52.8岁分别上升至60.5岁和57.6岁;男女比例右半结肠癌由1.38∶1下降至1.19∶1, 直肠癌无明显变化;全部结直肠癌构成中右半结肠癌无明显变化, 直肠癌构成从67.4%下降到61.8%;Dukes A期构成分别上升3.8%和2.6%, Dukes D期分别下降2.8%和3.7%。结论 近年来, 结直肠癌的发病率不断上升, 发病中位年龄上升, 直肠癌构成比下降, 右半结肠癌无明显变化, Dukes A期构成比增多, Dukes D期下降。

Study on the clinical characteristics of right colon cancer and rectal cancer

Objective Colorectal cancer in China has high morbidity and lethality and the epidemiologie characters such as increasing incidence, changing constituent ratio and clinical features. This study was to explore the clinical characteristics between right colon cancer and rectal cancer in Heilongjiang region among 15 years. Methods The clinical data of 2 552 cases were confirmed pathologically and divided into 5 - year groups were an- alyzed retrospectively. Result Compared with 1992 - 1997 group,right colon cancer and rectal cancer in the 2002 -2006 had the following characters ：the annual increase ratio were 6.7% and 6.0% respectively in hospitalization number; the median age of incidence increased from 53.1 and 52.8 to 60.5 and 57.6 respectively; the male/femal ratio decreased from 1.38：1 to 1.19：1 in right colon cancer and no significant variation was found in rectal cancer; the constituent ratio of rectal cancer decreased from 67.4% to 61.8% and right colon cancer no change ;the propor- tion of Dukes A stage increased 3.8% and 2.6% ,while Dukes D stage decreased 2.8% and 3.7% respectively. Conclusion In the past 15 years,the incidence of colorectal cancer were increasing in Heilongjiang province with an increase of median age of incidence; the constituent ratio of colorectal cancer were decreasing in rectal cancer and no change in right colon cancer,while Dukes A were increasing and Dukes D decreasing.