| 通脉复方微丸多元释药系统中丹参酮缓释单元的制备工艺 |
| |
| 引用本文： | 陈斌,萧伟,贾晓斌,黄洋.通脉复方微丸多元释药系统中丹参酮缓释单元的制备工艺[J].中国实验方剂学杂志,2012,18(4):39-42. |
| |
| 作者姓名： | 陈斌 萧伟 贾晓斌 黄洋 |
| |
| 作者单位： | 江苏省中医药研究院中药新型给药系统重点实验室,国家中医药管理局中药释药系统重点研究室,南京210028;中国制药过程新技术国家重点实验室,江苏康缘药业股份有限公司,连云港222001 |
| |
| 基金项目： | 江苏省中医药局中医药科技技术研究专项(LZ09061);国家中医药管理局中药释药系统重点研究室开放基金课题(2011NDDCM01002);中药制药过程新技术国家重点实验室开放课题(SKL2010Z0303) |
| |
| 摘 要： | 目的:优选丹参酮缓释微丸制备工艺.方法:将丹参酮组分制备成缓释固体分散体,考察乙基纤维素、羟丙甲基纤维素对其溶出度的影响；以丹参酮固体分散体作为主药制备微丸,考察处方中润湿剂、载药量、辅料、乳糖、润湿剂等因素对丹参酮微丸收率、圆整度的影响；采用正交试验设计筛选出丹参酮缓释微丸的最佳制备工艺.结果:丹参酮组分制备成缓释固体分散体,处方为乙基纤维素-丹参酮组分-羟丙甲基纤维素(3∶1∶0.5)；以固体分散体为主药制备成微丸,处方为丹参酮固体分散体20 g,乳糖6 g,微晶纤维素24 g,润湿剂为水33 mL,最佳工艺条件为挤出频率25 Hz,滚圆频率50 Hz,滚圆时间6min.结论:本工艺科学合理,制剂稳定,为通脉复方微丸多元释药系统的制备奠定了基础.
|
| 关 键 词： | 通脉复方微丸多元释药系统 丹参酮缓释单元 固体分散体 挤出滚圆 正交设计 |
Preparation Technology of Tanshinone Release Unit in Multi-drug Delivery System of Tongmai Compound Pellets |
| |
| CHEN Bin,XIAO Wei,JIA Xiao-bin and HUANG Yang.Preparation Technology of Tanshinone Release Unit in Multi-drug Delivery System of Tongmai Compound Pellets[J].China Journal of Experimental Traditional Medical Formulae,2012,18(4):39-42. |
| |
| Authors: | CHEN Bin XIAO Wei JIA Xiao-bin and HUANG Yang |
| |
| Institution: | Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine; Key Laboratory of Chinese Medicine Delivery System of State Administration of Traditional Chinese Medicine, Nanjing 210028, China; State Key Laboratory of Newtech Chinese Medicine Pharmacentical Process, Jiangsu Kanion Pharmacent Co. Ltd, Lianyungang 222001, China;Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine; Key Laboratory of Chinese Medicine Delivery System of State Administration of Traditional Chinese Medicine, Nanjing 210028, China; State Key Laboratory of Newtech Chinese Medicine Pharmacentical Process, Jiangsu Kanion Pharmacent Co. Ltd, Lianyungang 222001, China;Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine; Key Laboratory of Chinese Medicine Delivery System of State Administration of Traditional Chinese Medicine, Nanjing 210028, China; State Key Laboratory of Newtech Chinese Medicine Pharmacentical Process, Jiangsu Kanion Pharmacent Co. Ltd, Lianyungang 222001, China;Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine; Key Laboratory of Chinese Medicine Delivery System of State Administration of Traditional Chinese Medicine, Nanjing 210028, China; State Key Laboratory of Newtech Chinese Medicine Pharmacentical Process, Jiangsu Kanion Pharmacent Co. Ltd, Lianyungang 222001, China |
| |
| Abstract: | |
| |
| Keywords: | multi-drug delivery system of Tongmai compound pellets tanshinone release unit solid dispersion extrusion spheronization orhogonal design |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《中国实验方剂学杂志》浏览原始摘要信息 |
| 点击此处可从《中国实验方剂学杂志》下载免费的PDF全文 |
|
