补肾调经法治疗多囊卵巢综合征不孕症有效性与安全性的系统评价

目的 系统评价补肾调经法指导下补肾调经方剂联合促排卵药物治疗多囊卵巢综合征(polysystic ovary syndrome,PCOS)不孕症的有效性和安全性.方法 检索主要中英文数据库(中国知网、维普、万方、PubMed、Cochrane Library、Embase、Clinical Trials),检索时间为建...

Systematic review on efficacy and safety of Bushen Tiaojing therapy in treatment of polycystic ovary syndrome infertility

Objective To systematicly evaluate the efficacy and safety of Bushen Tiaojing Recipes combined with ovulation-induction drugs in the treatment of polycystic ovary syndrome (PCOS) infertility. Methods Databases including CNKI, VIP, Wan Fang, PubMed, Cochrane Library, Embase and Clinical Trials were searched from the establishment of the database to November, 2020. According to the inclusion and exclusion criteria, the randomized controlled trials (RCTs) of Bushen Tiaojing Recipes combined with ovulation-induction drugs in the treatment of PCOS infertility were collected, the data were extracted, and the quality of each study was evaluated with the "Cochrane bias risk assessment tool". The Meta analysis of the final indicators was analyzed by the Review Manager 5.3 software and the quality of evidence of the outcome indicators were evaluated according to the GRADE standard. Results A total of 28 RCTs with 2659 patients and 1337 cases in the treatment group and 1322 cases in the control group were enrolled. Systematic review results showed that:compared with single ovulation-induction drugs, Bushen Tiaojing Recipes combined with ovulation-induction drugs had significant effects on improving ovulation rate, pregnancy rate and androgen (T), luteinizing hormone (LH), reducing the incidence of adverse reactions and ovarian volume and increasing endometrial thickness (P<0.01). There was no significant difference in increasing estradiol (E2) and follicle stimulating hormone (FSH) between the two groups (P>0.05). The funnel plot of ovulation rate and pregnancy rate showed that each research point was asymmetric, suggesting that there might be publication bias. According to the GRADE method, the quality of evidence was low in ovulation rate and pregnancy rate and very low in other aspects. Conclusion Under the guidance of Bushen Tiaojing method, Bushen Tiaojing Recipes combined with ovulation induction drugs has fine clinical efficacy and good safety. However, due to the low quality of the included studies, clinical use still needs to be cautious.