丙戊酸治疗药物监测研究进展

丙戊酸在临床上主要用于各型癫痫的治疗，但其体内代谢个体差异大，有效血药浓度达标率低。有效血药浓度是保证疗效和减少毒副作用的重要前提，临床常采取血药浓度监测来提高丙戊酸血药浓度达标率，以保证癫痫治疗的有效性和安全性。从丙戊酸血药浓度监测方法、丙戊酸血药浓度与疗效的相关性、丙戊酸血药浓度与不良反应的相关性和丙戊酸血药浓度影响因素4方面做一综述，为开展有关丙戊酸血药浓度监测及合理用药提供参考。

Research progress of valproic acid therapy drug monitoring

Valproic acid is mainly used in the clinical treatment of various types of epilepsy, but there are great differences in the process of individual in vivo, and the effective blood concentration is low to meet the standard rate. The effective blood concentration is an important premise to ensure the efficacy and reduce the toxic and side effects. In order to ensure the effectiveness and safety of epilepsy treatment, plasma concentration monitoring is often adopted to improve the compliance rate of valproic acid plasma concentration.In this paper, the monitoring methods of valproic acid plasma concentration, the correlation between valproic acid plasma concentration and efficacy, the correlation between valproic acid plasma concentration and adverse reactions, and the influencing factors of valproic acid plasma concentration were reviewed in order to provide reference for the development of valproic acid plasma concentration monitoring and rational drug use.