中药调控肿瘤细胞自噬的研究进展

自噬是细胞自我吞食并通过溶酶体降解丧失功能的废旧细胞器和蛋白质等细胞内物质,以实现循环再利用、产生能量、对抗应激等现象.自噬可分为巨自噬、微自噬、分子伴侣介导的自噬3类.细胞自噬与肿瘤的增殖、凋亡、侵袭、转移和耐药性等密切相关.研究发现,中药能够增强肿瘤细胞自噬以诱导肿瘤细胞凋亡、抑制肿瘤细胞侵袭与转移、降低肿瘤耐药性...

Research progress on regulation of autophagy of tumor cells by traditional Chinese medicine

Autophagy is a cellular process of degradation of the worn and dysfunctional components, including proteins and organelles, in lysosomes to recycle cellular materials and supply energy under the stress situation. Autophagy falls into three categories, such as macroautophagy, microautophagy, and chaperone-mediated autophagy. It is well known that autophagy is associated with the proliferation, apoptosis, invasion, metastasis and chemoresistance of various cancer cells. Traditional Chinese medicine (TCM) may increase cancer autophagy to induce apoptosis, retard the invasion, metastasis and chemoresistance of a variety of cancers. However, some kinds of TCM may also enhance cancer autophagy to promote proliferation and suppress apoptosis of some cancer types. Besides, TCM may reduce the protective autophagy of certain cancers to reverse the therapeutic resistance. In addition, some TCM exhibit dual effects on cancer autophagy. The underlying mechanisms are the regulation of the mTOR-dependent pathway and the mTOR-independent pathway by TCM. With the development of autophagy biology, the innovation of TCM targeting cancer autophagy will be beneficial to the prevention and treatment of malignancies in the clinal setting.