电刺激小脑顶核对缺血性脑白质病病人认知及执行功能的影响

目的 探讨电刺激小脑顶核(FNS)对缺血性脑白质病(WMIL)病人认知功能及执行功能的影响.方法 选取核工业四一六医院2018年2月至2019年2月66例WMIL病人,随机数字表法分为基础组和研究组,均给予降低颅压、平衡体内水电解质、服用降脂降压、脑蛋白水解物类脑保护剂等常规治疗,研究组另施予FNS 1日1次,持续电刺...

Effect of fastigial nucleus electrical stimulation on cognition and executive function in patients with ischemic leukoencephalopathy

Objective To explore the effect of fastigial nucleus stimulation (FNS) on cognitive and executive functions in patientswith white matter ischemic lesions (WMIL).Methods Sixty-six patients with WMIL in Nuclear Industry 416 Hospital from February2018 to February 2019 were selected and assigned into the basic group and the study group by the random digital table method. All patients were given conventional treatment such as reducing intracranial pressure, balancing water and electrolyte in the body, taking lipid-lowering and antihypertensive drugs, brain protein hydrolysate brain protective agents and so on, and the study group was additionally given FNS once a day for continuous electrical stimulation. The treatment lasted for 3 months. Mini-mental state examination Scale (MMSE), Montreal Cognitive Assessment Scale (MoCA), Stroop Color-Word Test C (SCET-C), Clock Drawing Test (CDT) and Fractional Anisotropy (FA) in executive function-related brain areas were compared before and after treatment.Results There were no significant differences in MMSE and MoCA scores, SCWT-C and CDT test results and FA values between the two groups before treatment (P > 0.05). Three months after treatment, the MMSE and MOCA scores of the study group were increased, the SCWT-C accuracy rate was increased, the time-consuming was shortened, the CDT score was increased, and the FA of each brain area was increased in varying degrees, with statistically significant differences (P < 0.05). There was no significant difference in the basic group (P > 0.05). Three months after treatment, the MMSE scores [(17.86 ± 2.79) points], MOCA scores [(18.52 ± 3.86) points], SCWT-C accuracy rate results[correct rate (66.92 ± 5.29)%], CDT test results [(2.89 ± 0.26) points] and FA values of the study group were higher than those of the basic group [MMSE (14.58 ± 3.52) points, MOCA (14.81 ± 4.37) points, SCWT-C correct rate (49.42 ± 6.35)%, CDT (1.99 ± 0.41) points], with statistically significant differences (P < 0.05).Conclusion FNS therapy can improve the cognitive and executive functions of WMIL patients, and the short-term effect is definite.