乳疾灵胶囊联合乳腺增生口服液治疗乳腺增生的临床研究

目的 探讨乳疾灵胶囊联合乳腺增生口服液治疗乳腺增生的临床效果.方法 选取2019年1月—2020年3月濮阳市油田总医院收治的100例乳腺增生患者,以随机数字表法分为对照组(n=50)和治疗组(n=50).对照组口服乳腺增生口服液,20 mL/次,2次/d.治疗组在对照组基础上口服乳疾灵胶囊,3粒/次,3次/d.两组患者...

Clinical study on Rujiling Capsules combined with Ruxian Zengsheng Oral Liquid in treatment of mammary gland hyperplasia

Objective To investigate the clinical effect of Rujiling Capsules combined with Ruxian Zengsheng Oral Liquid in treatment of mammary gland hyperplasia.Methods A total of 100 patients with breast hyperplasia treated in Puyang Oilfield General Hospital from January 2019 to March 2020 were selected and divided into control group (n=50) and treatment group (n=50) by random number table method. Patients in the control group were po administered with Ruxian Zengsheng Oral Liquid, 20 mL/time, twice daily. Patients in the treatment group were po administered with Rujiling Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in both groups stopped taking medication during menstrual period, and each menstrual cycle was taken as a course of treatment. They were treated for 3 consecutive courses. After treatment, the clinical efficacy was evaluated, and the diameter of the tumor, the visual analog scale for milk pain (VAS) score, the score of 36 health survey short form (SF-36), and the serum sex hormones [estradiol (E₂), luteinizing hormone (LH), Progesterone (P)], pro-angiogenesis factors [vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF)] levels in two groups before and after treatment were compared.Results After treatment, the total effective rate of 96.0% in treatment group was significantly higher than that of control group (84.0%,P<0.05). After treatment, mass diameter and VAS score of breast pain were significantly decreased in both groups, but PCS score and MCS score were significantly increased (P<0.05). After treatment, mass diameter and VAS score in the treatment group were lower than those in the control group, but PCS score and MCS score were higher than those in the control group (P<0.05). After treatment, serum E₂ and LH levels in both groups were significantly lower than those before treatment, but serum P level was significantly higher than that before treatment (P<0.05). The improvement of serum sex hormone level in treatment group was more significant than that in control group (P<0.05). After treatment, the levels of serum VEGF and bFGF in two groups were significantly decreased compared with before treatment (P<0.05). The decrease of serum VEGF and bFGF in treatment group was more significant than that in control group (P<0.05).Conclusion Rujiling Capsules combined with Ruxian Zengsheng Oral Liquid has definite curative effect in treatment of mammary gland hyperplasia, and can effectively improve size of the lump, the symptoms of breast pain, and quality of life, and can correct the abnormal expression of sex hormones and pro-angiogenic factors in patients, which is worthy of clinical promotion and application.