含贝母药材的中药制剂质量控制研究的思考

贝母具有清热、化痰、止咳的功效,是治疗肺经疾病的要药,也是常见的中药材。《中国药典》2020年版收录浙贝母、川贝母、平贝母、伊贝母、湖北贝母5种贝母药材,其中,川贝母来源有6个基原,伊贝母2个基原,浙贝母、湖北贝母、平贝母各1个基原。通过对历版《中国药典》收录的贝母药材标准变化情况、贝母中生物碱类成分研究及《中国药典》2020年版含贝母药材中药制剂情况等方面的分析,提出对含贝母药材中药制剂质量控制的建议,为提高含贝母药材中药制剂的质量提供参考。

Consideration of quality control of traditional Chinese medicine preparations containing fritillaria

Fritillaria has the effects of clearing heat, resolving phlegm and relieving cough. It is an important medicine for the treatment of pulmonary meridian diseases and a common Chinese herbal medicine. 2020 Edition of Chinese Pharmacopoeia contains five species of fritillaria:Fritillariae Thunbergii Bulbus, Fritillariae Cirrhosae Bulbus, Fritillariae Ussuriensis Bulbus, Fritillariae Pallidiflorae Bulbus, Fritillariae Hupehensis Bulbus. Fritillariae Cirrhosae Bulbus has six origins. Fritillariae Pallidiflorae Bulbus has two origins. Fritillariae Thunbergii Bulbus, Fritillariae Hupehensis Bulbus and Fritillariae Ussuriensis Bulbus have one origin. Standard variation of fritillaria in different versions of Chinese Pharmacopoeia, study on alkaloids in fritillaria, and traditional Chinese medicine preparations containing fritillaria in 2020 edition of Chinese Pharmacopoeia were analyzed and studied, in order to put forward suggestions on quality control of traditional Chinese medicine preparations containing fritillaria, and provide references for improving the quality of traditional Chinese medicine preparations containing fritillaria.