| 基于HPLC指纹图谱和化学模式识别评价不同产地瓜蒌质量 |
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| 引用本文： | 王梦娇, 唐婷婷, 潘林梅, 付廷明, 李博, 朱华旭. 基于HPLC指纹图谱和化学模式识别评价不同产地瓜蒌质量[J]. 中国现代应用药学, 2021, 38(8): 919-924. DOI: 10.13748/j.cnki.issn1007-7693.2021.08.004 |
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| 作者姓名： | 王梦娇 唐婷婷 潘林梅 付廷明 李博 朱华旭 |
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| 作者单位： | 1.南京中医药大学, 江苏省中药资源产业化过程协同创新中心, 江苏省植物药深加工工程研究中心, 南京 210023 |
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| 基金项目： | 国家自然科学基金项目(81873013) |
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| 摘 要： | 目的 采用HPLC建立16批瓜蒌药材指纹图谱，结合化学模式识别的方法对不同产地瓜蒌进行区分。方法 采集不同产地瓜蒌药材的HPLC指纹图谱，利用
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| 关 键 词： | 瓜蒌 指纹图谱 相似度评价 聚类分析 主成分分析 |
| 收稿时间： | 2020-05-18 |
| 修稿时间： | 2020-10-09 |
Quality Evaluation of Trichosanthis Fructus in Different Origin Based on HPLC Fingerprint and Chemical Pattern Recognization |
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| WANG Mengjiao, TANG Tingting, PAN Linmei, FU Tingming, LI Bo, ZHU Huaxu. Quality Evaluation of Trichosanthis Fructus in Different Origin Based on HPLC Fingerprint and Chemical Pattern Recognization[J]. Chinese Journal of Modern Applied Pharmacy, 2021, 38(8): 919-924. DOI: 10.13748/j.cnki.issn1007-7693.2021.08.004 |
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| Authors: | WANG Mengjiao TANG Tingting PAN Linmei FU Tingming LI Bo ZHU Huaxu |
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| Affiliation: | 1.Nanjing University of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Jiangsu Research Center of Botanical Medicine Refinement Engineering, Nanjing 210023, China |
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| Abstract: | OBJECTIVE To establish an HPLC fingerprint method for 16 batches of Trichosanthis Fructus and distinguish Trichosanthis Fructus from different origins by chemical pattern recognization. METHODS The HPLC fingerprints of Trichosanthis Fructus from different origins were collected. The similarity of the obtained fingerprints were evaluated by the Chinese Medicine Chromatographic Fingerprint Similarity Evaluation System 2004A, then a common pattern was established. Based on its chemical fingerprint information, the quality of Trichosanthis Fructus was comprehensively analyzed by two kinds of chemical pattern recognition methods. RESULTS HPLC fingerprints of Trichosanthis Fructus were established, a total of 9 common peaks were calibrated and the similarity was basically >0.9. Cluster analysis and principal component analysis could clearly distinguish different origins, indicating that the main chemical marker causing the difference was vanillic acid, luteoloside, adenine, guanosine and xanthine. CONCLUSION Cluster analysis and principal component analysis can be used to definitely distinguish different Trichosanthis Fructus and comprehensively evaluate the quality of Trichosanthis Fructus from different origins. |
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| Keywords: | Trichosanthis Fructus fingerprint similarity evaluation cluster analysis principal component analysis |
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