阿托伐他汀对高脂血症患者胰岛素抵抗及C反应蛋白的影响

目的 观察阿托伐他汀对高脂血症患者胰岛素抵抗及C反应蛋白的影响.方法 82例高脂血症伴胰岛素抵抗患者给予阿托伐他汀20 mg/d,疗程12周.观察治疗前后血清总胆固醇（TC）、甘油三脂（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、空腹胰岛素（FINS）、胰岛素敏感指数（ISI）、C反应蛋白（CRP）及肝肾功能的变化.结果 阿托伐他汀治疗12周后患者TG、空腹胰岛素（FINS）、胰岛素敏感指数（ISI）及C反应蛋白（CRP）均降低（P＜0.05）,TC、LDL-C明显降低（P＜0.01）,伴有HDL-C明显升高（P＜0.01）,治疗前后肝、肾功能的比较无统计学意义（P＞0.05）.结论 阿托伐他汀具有调脂、改善胰岛素抵抗并有一定的抗炎作用.

Atorvastatin influence of hyperlipidemia in patients with insulin resistance and C-reactive protein

Objective To observe curative effect of atorvastatin in treating patients with hyperlipidemia and insulin resistance.Methods 82 patients with hyperlipidemia and insulin resistance given atorvastatin 20mg/d for 12 weeks.Total cholesterol（TC）,TG,LDL-C,HDL-C,fasting insulin （FINS）,insulin sensitivity index （ISI）,C-reactive protein （CRP）,liver function,kidney function were compared before and after treatment.Results After atorvastatin therapy for 12 weeks,the levels of TG,FINS,ISI and CRP were decreased （P〈0.05）,the levels of TC and LDL-C significantly decreased （P〈0.01）,while HDL-C was increased （P〈0.01）.The liver and kidney function showed no statistically significant before and after treatment （P〉0.05）.Gonclusion Atorvastatin statins have lipid mechanisms,improvement of insulin resistance and the anti-inflammatory effects.