The expression of the EBV latent membrane protein (LMP-1) is independent of CD23 and bcl-2 in Reed-Sternberg cells in Hodgkin's disease |
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| Authors: | AA ARMSTRONG A GALLAGHER AS KRAJEWSKI DB JONES BS WILKINS DE ONIONS RF JARRETT |
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| Institution: | Department of Veterinary Pathology, University of Glasgow, UK. |
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| Abstract: | A series of 33 cases of Hodgkin's disease was investigated for the presence of the EBV encoded latent gene product LMP-1 and of CD23 using immunohistochemical techniques. The expression of bcl-2 was examined in a subset of cases. LMP-1 was detected in the Reed-Sternberg cells in 15 cases. Although LMP-1 is known to upregulate CD23 and bcl-2, there was no correlation between the expression of LMP-1 and the detection of CD23 and bcl-2 in Reed-Sternberg cells. |
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| Keywords: | keywords Epstein-Barr virus Hodgkin's disease immunohistochemistry LMP-1 CD23 bcl-2 |
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