B cells behaving badly |
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| Authors: | Shim Youn K Silver Sharon R Caporaso Neil E Marti Gerald E Middleton Dannie C Linet Martha S Vogt Robert F |
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| Affiliation: | Division of Health Studies, Agency for Toxic Substances and Disease Registry, Atlanta, GA;, Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH;, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD;, Office of Cellular, Tissue and Gene Therapies, Center for Biologics Research and Evaluation, Food and Drug Administration, Bethesda, MD,;and Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA |
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| Abstract: | The pathogenesis of B-cell lymphoproliferative disorders in general and B-cell chronic lymphocytic leukaemia in particular appears to involve dysfunctional regulation of humoral and cellular immunity with the subsequent development of genetic aberrations in B cells. In theory, either component may arise de novo or may be influenced by environmental exposures including infectious agents, antigens, genotoxic chemicals, or radiation. As an intermediary within the exposure-disease continuum, monoclonal B-cell lymphocytosis may be a helpful biomarker for teasing out these various contributions to risk. This article introduces a series of papers that resulted from an International Workshop held in May 2007 entitled 'Monoclonal B-cell Lymphocytosis and Chronic Lymphocytic Leukemia: Environmental and Genetic Risk Factors'. Research efforts, such as those described in this issue, should lead to improved interventions, more predictive biomarkers, more effective treatments, and a greater appreciation of how the immune system functions over the entire human lifespan. |
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| Keywords: | chronic lymphocytic leukaemia monoclonal B-cell lymphocytosis aetiology genetics |
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