血浆脑钠肽水平在心房纤颤患者中的临床价值

目的：分析血浆脑钠肽（BNP）水平在心房纤颤患者复律前、后中的变化，评价其临床应用价值。方法：选取2010年12月-2013年12月本院确诊为心房纤颤且成功复律的57例患者作为观察组，依据发作时间分为两亚组：阵发性房颤（发作时间〈2 d）31例，持续性房颤（持续发作2 d-12个月）26例；选取同期在本院行健康检查正常者33例作为对照组，分析观察组复律前后的血浆BNP水平变化。结果：观察组复律前的血浆BNP比对照组高，比较差异有统计学意义（P〈0.05）；观察组两亚组的3项指标水平组间比较，差异差异有统计学意义（P〈0.05）；观察组患者的BNP水平与LEVF呈负相关性，与LVEDD呈正相关性，比较差异有统计学意义（P〈0.05）；观察组复律后、房颤复发患者的血浆BNP水平比对照组高，差异有统计学意义（P〈0.05）；窦律维持患者的血浆BNP水平与对照组比较，差异无统计学意义（P〉0.05）。结论：心房纤颤患者复律前血浆脑钠肽水平明显升高，复律后其显著下降，可用于评价房颤患者的发作时间和治疗预后效果。

Clinical Value of Plasma Brain Natriuretic Peptide Level in Patients with Atrial Fibrillation

Objective：To analyze the change of plasma brain natriuretic peptide （BNP） levels in patients with atrial fibrillation before and after cardioversion, and evaluate its clinical application value.Method： 57 cases diagnosed with atrial fibrillation and successful cardioversion of patients from 2010 December to 2013 December in our hospital were selected as observation group, according to the onset time they were divided into two sub groups： 31 cases with paroxysmal atrial fibrillation （time of onset 〈2 days） and 26 cases with persistent atrial fibrillation （continued to attack 2 days-12 months） 33 cases in our hospital for health examination for normal in the same period were selected as control group, the changes of plasma BNP levels before and after cardioversion were analyzed and observed.Result： The plasma BNP of the observation group was higher than that of the control group before the cardioversion, the difference was significant （P〈0.05）; three indexes of the two sub groups and the observation group were compared between groups, the difference was significant （P〈0.05）; the level of BNP of the observation group showed negative correlation to LEVF, and showed positive correlation to LVEDD, the difference was significant （P〈0.05）. After cardioversion, the BNP level of the patients for atrial fibrillation recurrence of the observation group was higher than that of the control group, the difference was significant （P〈0.05）. BNP level of patients with the maintenance of sinus rhythm had no significant difference from that of the control group （P〉0.05）.Conclusion： The plasma brain natriuretic peptide levels of patients with atrial fibrillation increase before cardioversion and decrease significantly after cardioversion, it can be used for the evaluation of the onset time and treatment prognosis.