前列地尔脂微球注射液治疗老年冠心病稳定型心绞痛的临床观察

目的：观察前列地尔脂微球注射液辅助治疗老年冠心病稳定型心绞痛的临床效果。方法：选取本院心内科2012年9月-2013年9月收治的120例老年冠心病稳定型心绞痛患者，按照随机数字表法将其分为前列地尔组和对照组各60例。对照组给予常规治疗，前列地尔组在常规治疗的基础上将前列地尔脂微球注射液10μg入小壶静脉滴注，1次/d。两组均以7 d为一疗程，共治疗3个疗程。观察两组患者心绞痛治疗总有效率、心电图总有效率、血液流变学指标改变情况和不良反应发生情况。结果：治疗3个疗程后，前列地尔组的心绞痛、心电图总有效率均明显高于对照组，两组治疗后各血液流变学指标均明显低于治疗前，且前列地尔组各血液流变学指标均明显低于对照组，差异均有统计学意义（P〈0.05）。两组均无严重不良反应发生。结论：前列地尔脂微球注射液辅助治疗老年冠心病稳定型心绞痛安全、有效，临床中可参考使用。

The Clinical Observation of Alprostadil Lipid-microsphere Injection in Treatment of Elderly Patients with Stable Angina Pectoris of Coronary Heart Disease

Objective：To observe the clinical effect of Lipo-PGE1 injection in treatment of elderly patients with stable angina pectoris of coronary heart disease.Method：120 stable angina patients in department of Cardiology from September 2012 to September 2013 were selected,they were divided into the alprostadil treatment group and the control group according to the random number table method,60 cases in each group.The control group was given conventional treatment,the alprostadil treatment group took the alprostadil Lipo-PGE1 injection of 10 μg into the small pot of intravenous injection on the basis of conventional therapy,1/d.Both of the two groups took 7 days for a course of treatment, a total of 3 courses of treatment.The total effective rate,total effective rate of ECG,blood rheology changes and adverse reactions of the two groups were observed.Result：After 3 courses of treatment,the angina pectoris and ECG total effective rate in alprostadil group were significantly higher than those of control group,the degree of blood rheology indexes of the two groups after treatment were significantly lower than before treatment,and those in the alprostadil group were significantly lower than the control group,the differences were statistically significant（P〈0.05）,and both of the two groups were no serious adverse reactions.Conclusion：Alprostadil lipid microsphere injection is safe and effective in the treatment of elderly patients with stable angina pectoris of coronary heart disease,clinical reference can be used.