联合用药治疗高血压的临床疗效观察

目的：探讨不同药理分类的抗高血压药物单独应用与联合应用的治疗效果。方法：将本院2011年2月-2014年2月收治的150例高血压患者随机分为三组，每组50例。A组患者口服钙通道阻滞剂维拉帕米， B组患者口服β-受体阻滞剂普萘洛尔；C组患者两种药物联合应用。三组均持续监测血压8周，对每组治疗效果及安全性进行观察及对比分析。结果：治疗8周后，C组治疗总有效率显著高于A、B两组（P〈0.05），三组患者平均血压分别下降30、28、50 mm Hg。C组不良反应发生率低于A、B两组，差异有统计学意义（P〈0.05）。结论：同时联合应用维拉帕米和普萘洛尔能有效控制患者血压，效果优于单独用药，且不良反应发生率相对较低，根据患者具体病因建议选择联合用药，本组合建议临床推广。

The Clinical Effect of Combination Treatment of High Blood Pressure

Objective：To study therapeutic effect of the different pharmacological classification of antihypertensive drugs used alone and combined use.Method：150 cases of hypertension were randomly divided into three groups in our hospital from February 2011 to February 2014,50 cases in each group.Group A were given oral calcium channel blockers verapamil.Group B patients were given oral beta blockers propranolol.Group C were given two drugs combined application. The course was 8 weeks,efficacy and safety of three groups were observed and compare.Result：8 weeks after treatment, the total effective rate of group C was significantly higher than that of groups A and B,the average blood pressure decreased respectively 30,28,50 mm Hg.Incidence of adverse reactions of group C was lower than that of group A and B,the difference was statistically significant（P〈0.05）.Conclusion：The combined used of verapamil and propranolol could effectively control the patient blood pressure,effect is better than alone,and the incidence of adverse reactions is relatively low.Combined therapy should be chosen and promoted according to the specific etiology.