多囊卵巢综合征患者血清色素上皮衍生因子水平变化及其意义研究

目的：探讨多囊卵巢综合征（PCOS）患者血清色素上皮衍生因子（PEDF）水平，并评价其激素水平和代谢指标之间的关系。方法：对本院近5年就诊的40例PCOS患者（PCOS组）与40例健康体检者（对照组）进行对比，评价两组患者的血清PEDF水平，并对两组有差异的指标与PEDF进行相关分析。结果：两组的BMI、糖代谢、脂代谢及激素水平比较差异均有统计学意义（P〈0.05），其余各项基础指标比较差异均无统计学意义（P〉0.05）。PCOS组BMI低于24 kg/m2的患者PEDF水平及hs-CRP均明显高于对照组（P〈0.01）。PCOS组BMI≥24 kg/m2的患者HOMA指数及PEDF水平均明显高于对照组（P〈0.01），hs-CRP明显高于对照组（P=0.03）。PEDF与hs-CRP（r=0.68，P〈0.05）、HOMA指数（r=0.32，P〈0.05）、BMI（r=0.29，P〈0.05）、腰臀比（r=0.31，P〈0.05）、舒张压（r=0.24，P〈0.05）、总胆固醇（r=0.33，P〈0.05）、甘油三酯（r=0.39，P〈0.05）及LDL-C（r=0.44，P〈0.05）正相关，而与HDL成负相关关系（r=-0.36，P〈0.05）。结论：PCOS患者中血清PEDF水平高于正常，特别是超重的PCOS患者血清PEDF显著升高，且与炎症反应、胰岛素抵抗指数及脂代谢情况关系密切。

The Expression and Significance of Pigment Epithelium-derived Factor in Patients with Polycystic Ovary Syndrome

Objective：To investigate the relationship between serum pigment epithelium -derived factor （PEDF） levels and hormone levels/ metabolic indicators in patients with polycystic ovary syndrome （PCOS）.Method：The clinical data of 40 PCOS patients （the PCOS group） and 40 healthy fertile women （the control group） were analyzed, the serum PEDF levels in two groups were detected. And the relationship of BMI, hs-CRP, HOMA index, waist-hip ratio, diastolic pressure, total cholesterol, triglyceride,and HDLwith PEDF were observed.Result：There were significant difference between the two groups in the terms of BMI, glucose metabolism, lipid metabolism and hormone levels （P〈0.05）, while the other remaining indicators were no difference between the two groups （P〉0.05）. For patients with BMI less than 24 kg/m2, the levels were significantly higher in the PCOS group than that in the control group in the terms of PEDF and hs-CRP （P〈0.01）; for patients with BMI≥24 kg/m2, HOMA index and PEDF were significantly higher in the PCOS group than that in the control group （P〈0.01）, hs-CRP was significantly higher than the control group （P=0.03）. PEDF was positively correlation with HOMA index （r=0.32,P〈0.05）, BMI （r=0.29,P〈0.05）, waist-hip ratio （r=0.31, P〈0.05）, diastolic blood pressure （r=0.24,P〈0.05）, total cholesterol （r=0.33,P〈0.05）, triglycerides （r=0.39,P〈0.05） and LDL-C （r=0.44,P〈0.05）, while it was negatively correlated with HDL （r=-0.36,P〈0.05）.Conclusions： Serum PEDF level in PCOS, especially in overweight patients, was higher than normal people. It is significantly corrected with inflammatory response, lipid metabolism and insulin resistance index.