辛伐他汀对STZ-糖尿病大鼠骨代谢指标及骨密度影响的实验研究

目的观察辛伐他汀对糖尿病大鼠血、尿I型胶原变联氨基末端肽(NTX)以及骨密度的影响,以了解他汀类药物对糖尿病性骨质疏松是否存在保护作用。方法健康雄性2月龄Wistar大鼠24只,体重(200±20)g,分为健康对照组(A组)、糖尿病组(B组)、辛伐他汀治疗组(C组)每组各8只。建立糖尿病大鼠模型后,检测各组第2周及第8周血糖、NTX,于第8周末处死大鼠,测定血NTX、全身骨密度及双侧股骨骨密度。结果第8周B组、C组骨密度较A组明显减低,C组经辛伐他汀治疗8周后骨密度较B组有所增加(P<0.05);B组和C组血、尿NTX显著高于A组(P<0.01);C组血、尿NTX低于与同期B组(P<0.05)。结论辛伐他汀对糖尿病大鼠骨质疏松存在一定程度的保护作用。

The effects of simvastatin on bone metabolism indexes and the bone mineral density in STZ induced diabetic rats

Objective To evaluate the effects of simvastatin on bone metabolism by measuring bone turnover markers NTX and bone mineral density（BMD） in STZ-induced diabetic rats. Methods 24 Wistar rats were randomly assigned to normal control group （ group A, n = 8 ） ,diabetic rats group （ group B, n = 8 ） and simvastatin （ 20 mg· kg^-1· d^-1） treatment diabetic group （group C, n = 8）. Urinary NTX were tested at the 2nd,8th week. Blood NTX and BMD were tested at the 8th week. Results ①At the 8th week, BMD in group B and C were lower than that of group A（P 〈0. 01 ）. BMD in group C was higher than that in group B（P 〈0. 05） ;serum NTX at the 8thweek and urinary NTX in group B,C at the 2th and 8th weeks were higher than those of group A（P 〈0. 01 ） ,while serum and urinary NTX in group C decreased significantly compared with those in group B （ P 〈 0. 05 ）. Conclusion Simvastatin could play a rote in the development of asteoporosis in diabetic rats.