Challenge reactions in atopic dermatitis after percutaneous entry of mite antigen |
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| Authors: | A GONDO N SAEKI Y TOKUDA |
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| Institution: | Department of Dermatology, Tokyo Medical College, Nishishinjuku 6-7-1, Shinjuku-ku, Tokyo 160, Japan |
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| Abstract: | We succeeded in reproducing an eczematous lesion on the apparently normal skin of a patient with atopic dermatitis by scratching and continuous application of an ointment containing ferritin-labelled mite antigen. Percutaneous entry of mite antigen was demonstrated in skin biopsies by Fe-staining. Scratched skin first showed an urticarial reaction typical of type I allergy which later changed into an eczematous reaction typical of type IV allergy. This change was also shown histologically. |
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