| 兔MCAO后脑组织和血浆内皮素的变化 |
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| 引用本文： | 张天锡,卞留贯,赵卫国.兔MCAO后脑组织和血浆内皮素的变化[J].中国神经精神疾病杂志,1995(2). |
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| 作者姓名： | 张天锡 卞留贯 赵卫国 |
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| 作者单位： | 上海第二医科大学瑞金医院神经外科，上海医科大学中山医院神经外科 |
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| 基金项目： | 卫生部“八五”攻关脑缺血课题基金 |
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| 摘 要： | 建立兔ＭＣＡＯ脑缺血模型。兔４８只随机分成４组：对照组Ｃ、脑缺血后２ｈ、４ｈ、２４ｈ组。用放免法测兔脑组织和血浆的内皮素含量。发现脑缺血后，缺血侧脑组织和血浆内皮素含量均显著高于对照组（Ｐ＜０．００１），且随缺血后时间的延长而递增（Ｐ＜０．０１）。内皮素与脑水含量之间呈显著正相关（Ｐ＜０．０５）。提示内皮素可能参与缺血脑损害并加重缺血后脑水肿。
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| 关 键 词： | 脑缺血，脑水肿，内皮素，大脑中动脉阻断 |
Changes of endothelin - 1 in cerebral cortex and plasma after cerebral ischemia |
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| . Zhang Tianxi,etal..Changes of endothelin - 1 in cerebral cortex and plasma after cerebral ischemia[J].Chinese Journal of Nervous and Mental Diseases,1995(2). |
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| Authors: | Zhang Tianxi etal |
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| Abstract: | Using rabbit middle cerebral artery occlusion (MCAO ) model, the contents of ET - 1 in cerebral cortex and plasma were measured by RIA.48 rabbits were randomly divided into 4 groups:control including sham-operated and normal control, 2h, 4h, 24h after cerebral ischemia (I2,I4, I24). We found that ET- 1 contents were significantly increased as compared with the control group (p<0.001 ) and changed much greater with the increasing ischemic time. There were positive correlation between brain ET - 1 and H2O (p<0.05). These results suggested that ET - 1 might take part in the ischemic brain injury and enhanced the ischemic brain edema. |
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| Keywords: | Cerebral ischemia Brain edemaEndothelin MCAO |
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