原发性高血压患者血清脂联素水平与IL-6的相关性

目的:探讨高血压患者血清脂联素(adiponectin，APN)水平，以及APN与白细胞介素-6(interlectin-6，IL-6)的相关性。方法: 选取原发性高血压患者60例(HT组，其中高血压Ⅰ级、Ⅱ级和Ⅲ级患者分别为20例)，健康对照者20例(Control组)，采用酶联免疫吸附法测定两组患者血清APN水平和IL-6水平。结果: 高血压患者血清APN水平［(8.2±3.8) mg/L］显著低于健康对照组［(10.4±2.9) mg/L］(P<0.05)，而IL-6水平［(81±4) μg/L］高于健康对照组［(18±5) μg/L］(P<0.05)，APN水平与IL-6呈负相关(r=-0.782，P<0.05)。多元回归分析表明，收缩压、高血压分级和IL-6水平可显著影响原发性高血压患者血清APN水平的变化。结论: 原发性高血压患者存在低脂联素血症，且与高血压严重程度密切相关。

Relationship between adiponectin and interleukin-6 in patients with essential hypertension

AIM:To explore the relationship between adiponectin and interleukin-6 (IL-6) in patients with essential hypertension (EH). METHODS: A total of 60 patients with EH (EH group, including 20 cases, respectively, of high blood pressure level 1, level 2 and level 3) and 20 healthy subjects (control group) were enrolled. Serum adiponectin and IL-6 concentrations were measured by enzyme-linked immunosorbent assay. RESULTS: Serum adiponectin concentration in EH group was significantly lower than in control group ［(8.2±3.8) mg/L vs. (10.4±2.9) mg/L, P<0.05］. However, the serum level of IL-6 in the EH group was higher than in the control group ［(81±4) μg/L vs. (18±5) μg/L, P<0.05］. Serum adiponectin concentration was negatively correlated with IL-6 (r=-0.782, P<0.05). Multiple regression analysis revealed that systolic blood pressure, severity of hypertension and IL-6 level significantly affected serum adiponectin level. CONCLUSION: Hypoadiponectinemia is present in patients with EH and adiponectin concentration is closely related with the severity of hypertension.