| 人胰腺癌裸鼠移植瘤系JF305的建立及生物学特性的研究 |
| |
| 引用本文： | 李昕 贾兰玲. 人胰腺癌裸鼠移植瘤系JF305的建立及生物学特性的研究[J]. 中国医科大学学报, 1993, 22(3): 161-163 |
| |
| 作者姓名： | 李昕 贾兰玲 |
| |
| 作者单位： | 中国医科大学肿瘤研究所胰癌研究室(李昕，张宝庚)，中国医科大学肿瘤研究所肺癌研究室(贾兰玲)，中国医科大学肿瘤研究所肺癌研究室(周伟红) |
| |
| 摘 要： | 采用手术切除人胰腺癌标本进行裸鼠皮下移植,建立了人胰晾癌裸鼠移植瘤系JF305,该瘤系具有移植成功率高、生长速度快的特点。其组织学和生物学研完基本保持了较好的稳定性。染色体分析以超二倍体为主,核型显示为人类染色体核型。因此,JF305是胰腺癌定位诊断和导向治疗研究的较好实验模型系统。
|
| 关 键 词： | 裸鼠 胰腺癌 移植 |
ESTABLISHMENT OF TRANSPLANTABLE HUMAN PANCREATIC CARCINOMA MODEL IN NUDB MICE AND STUDY OF ITS BIOLOGICAL CHARACTERISTICS |
| |
| Li Xin,Zhang Baogeng,Jia Lanling,. ESTABLISHMENT OF TRANSPLANTABLE HUMAN PANCREATIC CARCINOMA MODEL IN NUDB MICE AND STUDY OF ITS BIOLOGICAL CHARACTERISTICS[J]. Journal of China Medical University, 1993, 22(3): 161-163 |
| |
| Authors: | Li Xin Zhang Baogeng Jia Lanling |
| |
| Affiliation: | Cancer Research Institute |
| |
| Abstract: | A model of transplantable human pancreatic carcinoma in BALB/c nu/nu mice (JF305) was established. The tumor was obtained from a primary pancreatic carcinoma and has been maintained for 19 passages in 22 months. Morphological study showed that JF305 retained the original structure of human tumor. It has the features of high rate of success, and rapid growing. Chromosomal analysis of the tumor cells exhibited human origin with a hyperdiploid model.It seems that JF 305 can serve as a experimental model for the location diagnosis and target treatment of pancreatic carcinoma. |
| |
| Keywords: | nude mice pancreatic carcinoma transplantation |
| 本文献已被 CNKI 维普 等数据库收录！ |
