| 重症肝炎末梢血T细胞亚群分布的研究 |
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| 引用本文： | 周子文 吕先科. 重症肝炎末梢血T细胞亚群分布的研究[J]. 中国医科大学学报, 1993, 22(4): 292-293 |
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| 作者姓名： | 周子文 吕先科 |
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| 作者单位： | 中国医科大学附属第二医院传染科(周子文，刘沛，王兆荃，董祥家)，中国医科大学附属第二医院免疫室(吕先科) |
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| 摘 要： | 本文应用单克隆抗体APAAP法检测了重症肝炎末梢血中T细胞亚群的分布。结果:重症肝炎末梢血中CD_3~ ,和CD_8~ T细胞百分率较急性肝炎明显降低(P<0.01);重症肝炎死亡病例CD_8~ T细胞百分率随病情加重而下降,生存例CD_8~ T细胞百分率在病程中无明显变化。上述结果提示:重症肝炎的发生可能与CD_8~ T细胞大量聚集肝组织内有关。
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| 关 键 词： | 重症肝炎 T细胞亚群 病理生理学 |
Study of the Peripheral Blood T Lymphocyte Subtype in Fulminant Hepatitis |
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| Zhou Ziwen,Liu Pei,Wang Zhaoquan,et al. Study of the Peripheral Blood T Lymphocyte Subtype in Fulminant Hepatitis[J]. Journal of China Medical University, 1993, 22(4): 292-293 |
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| Authors: | Zhou Ziwen Liu Pei Wang Zhaoquan et al |
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| Abstract: | We investigated the peripheral brood T lymphocyte subtype in patients with fulrainant hepatitis and acute hepatitis by APAAP using monoclonal antibody. The findings presented in this study: (1) The percents of CD~ _3 and CD~ _5 T lymphocytes in cases with fulminant hepatitis were significantly lower than that in acute hepatitis (P<0.01). (2) The percent of CD~ _8 T lymphocyte in dead cases with fulminant hepatitis had descended following the exacerdation of this disease and no change of CD~ _8 T lymphocyte in survival cases. The results suggest that CD~ _6T lymphocyte gathered a great in liver may be involved in the development of fulminant hepatitis. |
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| Keywords: | fulminant hepatitis T lymphocyte subtype pathophysiology |
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