婴儿巨细胞病毒感染25例临床分析

目的: 探讨婴儿巨细胞病毒(cytomegalovirus,CMV)感染的临床特点、检测手段及治疗。方法: 对25例经酶免疫斑点技术确诊为CMV感染的婴儿的临床资料进行分析。结果: 支气管肺炎11例(44%),中枢神经系统损害11例(44%),高胆红素血症8例(32%),所有病例均给予更昔洛韦(ganciclovir,GCV)治疗,支气管肺炎治愈8例,好转3例;中枢神经系统损害治愈1例,好转9例,未愈1例;高胆红素血症治愈2例,好转6例。结论: 婴儿CMV感染以支气管肺炎、中枢神经系统损害和高胆红素血症为多见,血清特异性CMV-IgM抗体阳性为CMV感染的实验室诊断依据,GCV是治疗婴儿CMV感染的首选药物。

Cytomegalovirus infection in infants:Report of 25 cases

Objective:To explore the clinical features of infants infected with cytomegalovirus(CMV) and investigate the detection methods and treatment.Methods:The clinical data of 25 infants with CMV infection confirmed by detection of serum CMV-IgM using enzyme immunodot technic were analyzed.Results:Of the 25 patients,bronchopneumonia accounted for 11 cases(44%),central nervous system damage 11 cases(44%)and hyperbilirubinemia 8 cases(32%).All the patients were treated with ganciclovir.Bronchopneumonia was cured in 8 cases and improved in 3 cases.Central nervous system damage was cured in 1 case,improved in (9 cases) and uncured in 1 case.Hyperbilirubinemia was cured in 2 cases and improved in 6 cases.Conclusions:The most common manifestations of CMV infection in infants include bronchopneumonia,central nerves system damage and hyperbilirubinemia.The presence of serum CMV-IgM antibody is a laboratory diagnostic evidence.Ganciclovir is the choice of treatment for CMV infection.