甘氨双唑钠(CMNa)对肿瘤病人单剂量和多剂量药代动力学的比较

目的　研究甘氨双唑钠(CMNa)的单剂量和多剂量药代动力学，以对CMNa的蓄积性作一评价。方法　5名肿瘤病人, 连续9次, 静脉滴注剂量为700 mg/m²的CMNa静滴液，用HPLC-二极管阵列紫外法测定受试病人全血CMNa浓度, 并用开放型二室模型拟合CMNa的血药浓度-时间曲线。结果　CMNa在病人体内分布及消除都很快, 单剂量和多剂量静滴CMNa后血药浓度值和各药代动力学参数值非常相近，没有明显差别。结论　甘氨双唑钠在肿瘤病人体内不蓄积，是一个较安全的放疗增敏药物。

COMPARISON OF PHARMACOKINETICS OF SINGLE-AND MULTIPLE-DOSE OF GLYCODIDAZOLUM NATRIUM(CMNa) IN TUMOR PATIENTS

AIM　To study the pharmacokinetics of the new tumor radiosensitizer glycodidazolum natrium(CMNa) in tumor patients after single- and multiple-dose, in order to evaluate the accumulation of CMNa in patients. METHODS　5 tumor patients were given an intravenous dose of CMNa 700 mg/m² every other day for 9 times, and blood samples were collected at designed time after the first and the ninth CMNa administration. The blood concentrations of CMNa were determined by HPLC-UV. The blood concentration-time curves of CMNa after single-dose and multiple-dose were fitted to a two-compartment open model. RESULTS　CMNa was found to be distributed and eliminated rapidly in patients whether after single- or after multiple-dose. The blood concentration-time curves and pharmacokinetics parameters between single-dose and multiple-dose were similar, and they showed no significant difference. CONCLUSION　CMNa will not accumulate in patients′ bodies, and it is a safe drug.