| HO-1抗氧化损伤的研究进展 |
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| 引用本文： | 朱子夫. HO-1抗氧化损伤的研究进展[J]. 医学综述, 2010, 16(15): 2266-2270 |
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| 作者姓名： | 朱子夫 |
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| 作者单位： | 昆明医学院第一附属医院麻醉科,昆明,650032 |
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| 摘 要： | 血红素氧合酶1(HO-1)催化血红素降解生成胆红素,一氧化碳和Fe2+,这个表面平淡无奇的催化反应却引起人们越来越多的注意。HO-1的活性直接影响到抗氧化损伤的能力的变化。现已证实HO-1具有抗炎、抗凋亡、抗增殖的作用。同时还发现,在许多疾病(如败血症和动脉粥样硬化)中起着保护作用。但是,HO-1产生保护作用的机制现在仍然没有完全明确,本综述重点介绍HO-1的功能。
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| 关 键 词： | 血红素氧合酶1 氧化损伤 细胞凋亡 |
Study on Heme Oxygenase Protection Against Oxidative Injury |
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| ZHU Zi-fu. Study on Heme Oxygenase Protection Against Oxidative Injury[J]. Medical Recapitulate, 2010, 16(15): 2266-2270 |
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| Authors: | ZHU Zi-fu |
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| Abstract: | Heme oxygenase-1(HO-1)functions to catabolize heme into bilirubin,carbon monoxide,and free iron.Remarkably,however,such common activity of this enzyme results in profound changes in cellular abilities to protect themselves against oxidative injuries.HO-1 has been shown to have anti-inflammatory,antiapoptotic,and antiproliferative effects,and it is now known to have beneficial effects in diseases such as atherosclerosis and sepsis.The mechanism through which HO-1 confers its protective effects is still poorly understood.This review highlights the current study on the function of HO-1. |
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| Keywords: | Heme oxygenase Oxidative injuries Apoptosis |
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