| 非对称性二甲基精氨酸与糖尿病脑血管病变 |
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| 引用本文： | 薛波,赵玉武. 非对称性二甲基精氨酸与糖尿病脑血管病变[J]. 国际脑血管病杂志, 2010, 18(6). DOI: 10.3760/cma.j.issn.1673-4165.2010.06.011 |
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| 作者姓名： | 薛波 赵玉武 |
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| 作者单位： | 215007,苏州大学附属第一医院;200233,上海交通大学附属第六人民医院神经内科;上海交通大学附属第六人民医院神经内科,200233 |
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| 摘 要： | 一氧化氮(nitric oxide,NO)是已知最重要的内源性血管舒张因子.内皮型一氧化氮合酶(nitric oxide and enzyme,NOS)的竞争性抑制剂非对称性二甲基精氨酸(asymmetric dimethylarginine,ADMA)可抑制NO的合成,使NO/NOS通路发生障碍,NO合成减少.近年来的研究表明,ADMA与糖尿病脑血管病变的发生和发展有关,为进一步明确该病的发生机制提供了新的见解.
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| 关 键 词： | 精氨酸 一氧化氮合酶 一氧化氮 糖尿病 脑血管障碍 |
Asymmetric dimethylarginine and diabetes with cerebrovascular diseases |
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| XUE Bo,ZHAO Yu-wu. Asymmetric dimethylarginine and diabetes with cerebrovascular diseases[J]. International Journal of Cerebrovascular Diseases, 2010, 18(6). DOI: 10.3760/cma.j.issn.1673-4165.2010.06.011 |
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| Authors: | XUE Bo ZHAO Yu-wu |
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| Abstract: | Nitric oxide (NO) is the most important known endogenous vasodilator factor. The competitive inhibitor asymmetric dimethylarginine (ADMA) of endothelial nitric oxide synthase (NOS) inhibits NO synthesis, which makes NO/NOS pathway to be obstructed and the reduction of NO synthesis. The studies in recent years have suggested that ADMA is as-sociated with the occurrence and development of diabetes with cerebrovascular disease. It has provided new insights into further clarifying the mechanism of the disease. |
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| Keywords: | Arginine Nitric oxide synthase Nitric oxide Diabetes mellitus Cerebrovascular disorders Arteriosclerosis |
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