livin和P53蛋白在胃癌及癌旁组织中的表达及临床意义

目的探讨livin和P53在胃癌及癌旁组织中的表达及临床意义。方法应用免疫组织化学方法检测40份胃癌组织及癌旁正常组织中livin和P53蛋白表达情况。结果胃癌组织中livin和P53蛋白阳性表达率分别为47.5%和52.5%,癌旁正常组织中阳性表达率分别为5.0%和12.5%,差异有统计学意义(P<0.05);伴淋巴结转移的胃癌组织中livin表达阳性率高于无淋巴结转移的胃癌组织(P<0.05),Ⅲ+Ⅳ期胃癌组织中livin及P53蛋白阳性表达率高于Ⅰ+Ⅱ期(P<0.05);livin与P53蛋白表达无相关性(P>0.05)。结论 livin与P53蛋白异常表达与胃癌的恶性生物学行为有关,其表达对临床上判断胃癌的预后有重要意义。

Expressions and clinical significance of livin and P53 protein in gastric carcinoma and its adjacent tissue

Objective To investigate the expressions of protein livin and P53 protein in gastric carcinoma and its adjacent tissue.Methods The expressions of livin and P53 protein from 40 specimens of gastric carcinoma and their adjacent tissues were detected by immunohistochemistry.Results The positive expressive rates of livin and P53 protein were 47.5% and 52.5% in specimens from gastric carcinoma,significantly different from those in their adjacent tissue(5.0% and 12.5%)(P<0.05).The positive rate of livin in gastric carcinoma with lymph node metastasis was significantly higher than that without lymph node metastasis(P<0.05).The positive rates of livin and P53 protein in gastric carcinoma of PTNM Ⅲ+Ⅳ were significantly higher than those of PTNM Ⅰ+Ⅱ(P<0.05).The expression of livin was not correlated with the expression of P53 protein(P>0.05).Conclusion The abnormal expressions of livin and P53 are correlated with malignant biological behaviors of gastric cancer,which plays an important role in judging the prognosis of gastric carcinoma.