喹硫平与利培酮治疗老年痴呆精神行为障碍对照研究

目的:探讨喹硫平和利培酮对老年期痴呆患者精神行为症状(BPSD)的疗效和安全性。方法:将60例老年期痴呆伴BPSD患者随机分成两组,分别使用喹硫平和利培酮治疗8周,采用痴呆病理行为评定量表(BEHAVE-AD)、激越行为量表(CMAI)及治疗中出现的药物副反应量表(TESS)评定疗效和不良反应。结果:两组治疗前后BEHAVE-AD和CMAI评分显著下降(P<0.01),两组患者之间治疗前后BE-HAV-AD总减分值差异无统计学意义(P>0.05),但情感障碍和焦虑两因子减分值差异有统计学意义(P<0.05),利培酮组的锥体外系反应、口干、便秘、头昏等较喹硫平组显著(P<0.01)。结论:喹硫平和利培酮对老年痴呆患者精神症状的疗效相当,喹硫平对情感症状和焦虑的疗效更明显、安全性更高。

Control study of Quetiapine and Risperidone in the treatment of mental and behavioral disorders of senile dementia

Objective:To explore the efficacy and safety of Quetiapine and Risperedone in the treatment of psychiatric and behave symtoms of senile dementia.Methods:60 patients with BPSD were randomly divided into Quetiapine group and Risperidone group,treatment for 8 weeks.BEHAVE-AD,CMAI and TESS were used to evaluate efficacy and side effect.Results:The score of BEHAVE-AD and CMAI decreased significantly(P<0.01),no difference was found in the decreased score of BEHV-AD between the two groups(P>0.05),but the decreased scores of the mood disorder factor and anxiety disorder factor between the two groups were difference(P<0.05).Extrapyramidal symptoms,dry mouth,constipation,dizziness and other in Risperidone group were significantly than that in Quetiapine group(P<0.01).Conclusion:Quetiapine is as effective as Risperidone for treatment of mental and behavioral disorders of senile dementia,Quetiapine has better efficacy and higher safety for treatment of mood disorder and Anxiety disorder.