儿童先天性心脏病体外循环术后呼吸道合胞病毒感染临床研究

目的探讨先天性心脏病(先心病)体外循环术后呼吸道合胞病毒感染的特点、转归及治疗原则。方法回顾性分析2 423例行体外循环心脏畸形矫治术患儿临床资料,对术后发生呼吸道合胞病毒感染的11例患儿进行统计分析。结果先心病体外循环术后呼吸道合胞病毒感染发生率为0.46%,11例感染患儿中死亡6例;术后ICU停留中位时间25d,机械通气中位时间429h;二次气管插管8例,使用经鼻持续气道正压通气4例,使用高频振荡呼吸机通气7例;术后合并其他细菌感染8例,其中多重感染5例。结论先心病体外循环术后呼吸道合胞病毒感染的发生率低,但病情进展迅速、预后不良。

Research of respiratory syncytial virus infection in children with congenital heart disease after cardiopulmonary bypass surgery

Objective To investigate and summary the characteristics,outcome and treatment principles of respiratory syncytial virus infection in children with congenital heart disease after cardiopulmonary bypass surgery.Methods The clinical data of 11 patients with respiratory syncytial virus infection after cardiopulmonary bypass surgery were retrospectively studied out of 2 423 cases receiving cardiopulmonary bypass surgery.Results The incidence of respiratory syncytial virus infection in patients after cardiopulmonary bypass surgery was 0.46%.Six patients died.The median time of ICU stay was 25 days.The median time of mechanical ventilation was 429 hours.Reintubation was performed in 8 cases.Nasal continuously positive airway pressure was given in 4 cases,and high frequency oscillation ventilator was given in 7 cases.Bacterial infection occurred in 8 cases,in which 5 cases were found multiple infections.Conclusion The incidence of respiratory syncytial virus infection in patients after cardiopulmonary bypass surgery is lower,but the progress of the patients’ station is rapid,the length of the infection is long and the prognosis is poor.