培哚普利联合美托洛尔治疗高血压并阵发性心房颤动临床研究

目的评价培哚普利与美托洛尔联合治疗高血压合并阵发性心房颤动(房颤)的长期疗效。方法 109例高血压合并阵发性房颤患者,随机分为观察组52例与对照组57例,观察组给予培哚普利和美托洛尔缓释片治疗,对照组给予无血管紧张素转化酶抑制剂类药物的常规治疗,随访2a,比较2组治疗后12个月内房颤发生次数及治疗前和治疗后12,24个月左心房内径。结果治疗后12,24个月,观察组与治疗前及同期对照组比较,左心房内径差异均无统计学意义(P>0.05);观察组房颤发生次数较治疗前明显减少(P<0.05),对照组与治疗前比较差异无统计学意义(P>0.05)。结论应用培哚普利和美托洛尔联合治疗高血压合并阵发性房颤,在控制患者血压达标同时可减少房颤发生次数。

Perindopril plus metoprolol in the treatment of hypertension complicated with paroxysmal atrial fibrillation

Objective To evaluate the long-term efficacy of perindopril plus metoprolol on hypertension complicated with paroxysmal atrial fibrillation(PAF).Methods A total of 109 hypertensive patients complicated with PAF were randomly divided into the observation group(n=52) receiving perindopril plus metoprolol and control group(n=57) receiving regulation treatment without angiotensin converting enzyme inhitor.The frequency of PAF 12 months after treatment,and the left atrial diameter(LAD) before and 12 and 24 months after treatment were compared between two groups.Results In 12-and 24-month follow-up,compared with before treatment and control group,there was no significant difference in LAD in the observation group(P>0.05),and the frequency of PAF was much lower in the observation group(P<0.05).There was no significant difference after treatment in comparison with before treatment in control group(P>0.05).Conclusion Perindopril plus metoprol can reduce the frequency of PAF while effectively controlling blood pressure in hypertensive patients complicated with PAF.