急性冠状动脉综合征患者血清高迁移率族蛋白-1水平与左室射血分数相关性研究

目的评价血清高迁移率族蛋白-1(high mobility group box-1,HMGB-1)与急性冠状动脉综合征患者左室射血分数的关系。方法急性冠状动脉综合征患者121例(ACS组)及体检健康者42例(对照组),比较2组血清HMGB-1水平及左室射血分数、左心室舒张期末径、左心室收缩期末径及二尖瓣口血流E/A峰值比。结果 ACS组患者血清HMGB-1水平明显高于对照组(P<0.05);与对照组比较,ACS组左室射血分数及E/A明显降低,而左心室收缩期末径明显增大(P<0.05);血清HMGB-1水平与左室射血分数呈明显负相关(r=-0.299,P<0.01)。结论血清HMGB-1水平可反映急性冠状动脉综合征患者的左室射血分数,有助于评价其心脏收缩功能。

Association of serum high mobility group box-1 level with left ventricular ejection fraction in patients with acute coronary syndrome

Objective To investigate the association of high mobility group box-1(HMGB-1) level with the left ventricular ejection fraction(LVEF) in patients with acute coronary syndrome(ACS).Methods A total of 121 patients with ACS and 42 healthy controls were compared serum HMGB-1 level,LVEF,left ventricular end diastolic diameter(LVDD),left ventricular end systolic diameter(LVDS) and mitral valve E/A.Results Serum HMGB-1 level was significantly higher in ACS group than that in control group(P<0.01).LVEF and mitral valve E/A were significantly lower,and LVDS was significantly longer in ACS group compared with control group(P<0.05).HMGB-1 level was significantly and negatively correlated with LVEF(P<0.01).Conclusion Serum HMGB-1 level can reflect the LVEF value,which helps to evaluate cardiac systolic function in patients with ACS.