| 慢性重型肝炎患者终末期肝病模型评分、甲胎蛋白与胰岛素抵抗关系探讨 |
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| 引用本文： | 伍利利,彭婷婷,白文静,王小青. 慢性重型肝炎患者终末期肝病模型评分、甲胎蛋白与胰岛素抵抗关系探讨[J]. 中华医院感染学杂志, 2011, 21(16): 3406-3408 |
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| 作者姓名： | 伍利利 彭婷婷 白文静 王小青 |
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| 作者单位： | 温州市第二人民医院检验科,浙江,温州,325000 |
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| 摘 要： | 目的探讨慢性重型肝炎患者终末期肝病模型(MELD)评分和甲胎蛋白与胰岛素抵抗的关系。方法选择慢性重型肝炎患者95例,正常对照组80例,检测甲胎蛋白及按MELD系统进行评分,所有患者进行空腹及早餐后2 h血糖、胰岛素测定,计算胰岛素敏感性指标(ISI)、胰岛细胞分泌功能指标(HOMA-IS)及胰岛素抵抗指数(HOMA-IR)并进行比较。结果慢性重型肝炎患者组的ISI、HOMA-IS明显低于正常对照组,差异有统计学意义(P<0.05),而HOMA-IR明显高于正常对照组,差异有统计学意义(P<0.05);慢性肝病患者MELD评分<10、10~29、>30分组的ISI及HOMA-IS分别为-(4.1±0.3)、-(4.6±0.8)、-(5.7±0.9)及4.2±0.4、3.6±0.7、2.9±0.8,其两两比较,差异有统计学意义(P<0.05),而HOMA-IR水平依次升高;慢性重型肝炎患者甲胎蛋白水平50~200、200~500、>500μg/L组的ISI、HOMA-IS、依次降低,差异有统计学意义(P<0.05),而HOMA-IR水平依次升高。结论联合慢性重型肝炎患者MELD评分和甲胎蛋白检测,可以评估患者的胰岛素抵抗程度。
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| 关 键 词： | 慢性 重型肝炎 终末期肝病模型评分 甲胎蛋白 胰岛素 抵抗 |
Relationship between MELD score, alphafetoprotein and insulin resistance in patients with chronic severe hepatitis |
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| WU Li-li,PENG Ting-ting,BAI Wen-jing,WANG Xiao-qing. Relationship between MELD score, alphafetoprotein and insulin resistance in patients with chronic severe hepatitis[J]. Chinese Journal of Nosocomiology, 2011, 21(16): 3406-3408 |
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| Authors: | WU Li-li PENG Ting-ting BAI Wen-jing WANG Xiao-qing |
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| Affiliation: | (The Second People′s Hospital of Wenzhou,Wenzhou,Zhejiang 325000,China) |
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| Abstract: | OBJECTIVE To study the relationship between the MELD score,alphafetoprotein and Insulin resistance in chronic severe hepatitis.METHODS Ninety-five cases with chronic severe hepatitis were chosed,eighty cases as normal control group,the alpha fetoprotein levels were detected and scored by MELD system.For fasting and 2 h after breakfast,the blood glucose,insulin determination,calculated insulin sensitivity index(ISI),pancreatic islet cell function index(HOMA-IS) and insulin resistance index(HOMA-IR) were comp... |
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| Keywords: | Chronic Severe hepatitis Model for end-stage liver disease score Alpha fetoprotein Insulin Resistance |
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