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| 延长哌拉西林/他唑巴坦输注时间治疗革兰阴性杆菌感染的临床研究 | |
| 引用本文： | 叶龙强,蔡挺,金雨虹,许兆军,朱宝琦,李桃红,张顺. 延长哌拉西林/他唑巴坦输注时间治疗革兰阴性杆菌感染的临床研究[J]. 中华医院感染学杂志, 2011, 21(16): 3476-3479 |
| 作者姓名： | 叶龙强 蔡挺 金雨虹 许兆军 朱宝琦 李桃红 张顺 |
| 作者单位： | 1. 宁波市医疗中心李惠利医院ICU,浙江,宁波,315040 2. 宁波市第二医院呼吸内科,浙江,宁波,315010 3. 宁波市第二医院ICU,浙江,宁波,315010 4. 宁波市第二医院中心实验室,浙江,宁波,315010 |
| 基金项目： | 浙江省医药卫生科技计划，宁波市自然科学基金 |
| 摘 要： | 目的评价延长哌拉西林/他唑巴坦输注时间治疗革兰阴性杆菌感染的疗效及安全性。方法采用前瞻性、随机对照研究,根据哌拉西林/他唑巴坦的给药时间随机分为两组,即延长3 h输注治疗组和常规30 min输注治疗组,观察两组患者的临床疗效和不良反应。结果 66例患者完成治疗疗程;延长输注组35例,治疗有效率为68.6%,细菌清除率为42.8%;常规输注组31例,治疗有效率为41.9%,细菌清除率32.2%;两组间临床有效率差异有统计学意义,而细菌清除率差异无统计学意义。结论哌拉西林/他唑巴坦的延长输注方案优于常规输注方案。 |
| 关 键 词： | 哌拉西林/他唑巴坦 革兰阴性杆菌 延长输注 |
Clinical study on extending infusion time of piperacillin/tazobactam in treatment of gram-negative bacteria infection |
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| YE Long-qiang,CAI Ting,JIN Yu-hong,XU Zhao-jun,ZHU Bao-qi,LI Tao-hong,ZHANG Shun. Clinical study on extending infusion time of piperacillin/tazobactam in treatment of gram-negative bacteria infection[J]. Chinese Journal of Nosocomiology, 2011, 21(16): 3476-3479 | |
| Authors: | YE Long-qiang CAI Ting JIN Yu-hong XU Zhao-jun ZHU Bao-qi LI Tao-hong ZHANG Shun |
| Affiliation: | YE Long-qiang,CAI Ting,JIN Yu-hong,XU Zhao-jun,ZHU Bao-qi,LI Tao-hong,ZHANG Shun(Lihuili Hospital,Ningbo Medical Center,Ningbo,Zhejiang 315040,China) |
| Abstract: | OBJECTIVE To evaluate the clinical efficacy and safety of extending the administration time of piperacillin/tazobactam in the treatment of Gram-negative bacteria infection.METHODS A prospective,randomized,controlled clinical study was conducted to compare the clinical efficacy and side-effects of prolonged infusion(3h) versus traditional infusion(30min) of piperacillin-tazobactam in patients with Gram-negative bacteria infection.RESULTS Thirty-five patients were enrolled in prolonged infusion group of piper... |
| Keywords: | Piperacillin/tazobactam Gram-negative bacteria Extending infusion |
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