| 慢性肾衰竭患者腹水高迁移率族蛋白检测及其意义 |
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| 引用本文： | 王婷婷,刘鸿生,蒋华振,陈国千.慢性肾衰竭患者腹水高迁移率族蛋白检测及其意义[J].中华医院感染学杂志,2011,21(16):3373-3374. |
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| 作者姓名： | 王婷婷 刘鸿生 蒋华振 陈国千 |
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| 作者单位： | 南京医科大学附属无锡人民医院医学检验科,江苏,无锡,214023 |
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| 摘 要： | 目的研究高迁移率族蛋白B1(HMGB1)在慢性肾衰竭及并发感染患者腹水中的水平变化及其临床意义。方法采用ELISA法对35例临床腹水标本(其中慢性肾衰竭无并发症10例,肾衰竭并发肺炎12例,肾衰竭并发腹膜炎13例)进行HMGB1检测,同时检测所有研究对象血液中的CRP水平。结果肾衰竭并发腹膜炎(C)组腹水(渗出液)HMGB1水平明显高于慢性肾衰竭无并发症(A)组及肾衰并发肺炎(B)组(漏出液),差异有统计学意义(P<0.01),A组与B组腹水中HMGB1水平的差异无统计学意义;B组和C组血液中的CRP水平明显高于A组,差异有统计学意义(P<0.01),提示体内存在感染。结论腹水HMGB1检测对慢性肾衰竭患者腹水性质的鉴别有较好的临床意义,若联合血液CRP指标的检测对临床鉴别诊断慢性肾衰竭有无并发其他感染性疾病也具有一定意义。
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| 关 键 词： | 高迁移率族蛋白B1 腹腔 积液 |
Detection of ascitic fluid HMGB1 in patients with chronic renal failure and its significance |
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| WANG Ting-ting,LIU Hong-sheng,JIANG Hua-zhen,CHEN Guo-qian.Detection of ascitic fluid HMGB1 in patients with chronic renal failure and its significance[J].Chinese Journal of Nosocomiology,2011,21(16):3373-3374. |
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| Authors: | WANG Ting-ting LIU Hong-sheng JIANG Hua-zhen CHEN Guo-qian |
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| Institution: | (Wuxi People′s Hospital,Wuxi,Jiangsu 214023,China) |
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| Abstract: | OBJECTIVE To investigate the clinical significance of HMGB1 level in ascitic fluid from chronic renal failure patients complicated with infection.METHODS HMGB1 level were detected by ELISA in ascitic fluid of 10 chronic renal failure patients without infection(group A),12 with pneumonia(group B) and 13 with peritonitis(group C).Serum CRP were also detected in all 35 chronic renal failure patients.RESULTS The average level of HMGB1 in exudates(group C) was significantly higher than transudates(including grou... |
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| Keywords: | HMGB1 protein Abdominal cavity Fluid |
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