医院获得性肺炎病原菌的耐药性分析

目的探讨临床细菌性肺炎感染病原菌的种类、分布特征和耐药性,为细菌性肺炎患者抗感染治疗提供方案。方法对2008年3月-2009年11月临床痰液标本中分离的病原菌进行菌株鉴定,采用K-B法,按照NCCLS规定标准进行药敏试验判断。结果革兰阴性杆菌占67.7%;革兰阳性球菌以及真菌分别占20.4%和11.9%;前3位病原菌依次为铜绿假单胞菌、肺炎克雷伯菌和白色假丝酵母菌,分离率分别为28.7%、18.3%和11.1%;革兰阴性杆菌对氨苄西林、哌拉西林、四环素和呋喃妥因耐药较严重;革兰阳性球菌对阿奇霉素、氨苄西林、青霉素和苯唑西林耐药较严重。结论病原菌对抗菌药物具有严重的多药耐药性;加强耐药性监测,合理选择应用抗菌药物,以提高细菌性肺炎抗感染的治愈率。

Drug resistance of pathogens causing hospital acquired bacterial pneumonia

OBJECTIVE To explore the distribution and the drug-resistance of pathogens for the clinical bacterial pneumonia and provide anti-infective therapy.METHODS From Mar 2008 to Nov 2009,all pathogens isolated from sputum specimens were identified and evaluated by ATB Expression system and K-B paper disk diffusion in accordance with NCCLS Standards.RESULTS Gram-negative bacilli accounted for 67.7%,Gram-positive bacilli and fungi accounted for 20.4% and 11.9% respectively.The top three pathogens were Pseudomonas a...