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护肝解纤汤治疗大鼠肝纤维化的作用观察
引用本文:舒建昌,邓亮,吕霞,何雅军,朱海燕,付景,叶国荣,周海华. 护肝解纤汤治疗大鼠肝纤维化的作用观察[J]. 国际中医中药杂志, 2010, 32(1): 197-199. DOI: 10.3760/cma.j.issn.1673-4246.2010.03.001
作者姓名:舒建昌  邓亮  吕霞  何雅军  朱海燕  付景  叶国荣  周海华
作者单位:广东省暨南大学医学院附属广州红十字会医院消化内科,510220;
基金项目:广东省科学技术厅课题广东省中医药局科研课题广州市医药卫生科技项目
摘    要:Objective To observe therapeutic effects of HuGanJieXian decoction on rats hepatic fibrosis induced by tetrachloride. Methods Rat models of hepatic fibrosis were constructed by intraperitoneal injection of tetrachloride.HuGanJieXian decoction composed of low, middle, and high dose curcumin were given to these rats respectively at the same time. Sho-saiko-to compound treatment group and Fufangbiejiarangan Tablets treatment group were made as positive control groups. After twelve weeks, all rats were executed. Serum samples were kept for measuring serum levels of PC-Ⅲ, LN, and HA. Left livers were extirpated for pathologic examination including H.E and Masson stainings. Grade of hepatic fibrosis were evaluated according to SSS system. The levels of superoxide dismutase (SOD) and malondialdehyde (MDA) of supematant centrifugated from hepatic tissue homogenate were detected. Results Serum levels of PC-Ⅲ, LN, and HA were depressed obviously in decoction groups compared with those of fibrotic group (P<0.05) , especially in the low-dose curcumin group.HuGanJieXian Decoction could increase the level of SOD and decrease the level of MDA (P<0.05) , especially in the low-dose curcumin group. Staining of H. E and Masson showed that degrees of hepatic fibrosis in decoction groups were improved obviously compared with that of the fibrotic group. Conclusion HuGanJieXian Decoction can improve rat hepatic fibrosis, the mechanism of this effect may be associated with protecting hepatic cell membrane and anti- peroxidative damage.

关 键 词:肝纤维化   护肝解纤汤   过氧化损伤   

Therapeutic effect of HuGanJieXian decoction on rats hepatic fibrosis
SHU Jian-chang,DENG Liang,L Xia,HE Ya-jun,ZHU Hai-yan,FU Jing,YE Guo-rong,ZHOU Hai-hua. Therapeutic effect of HuGanJieXian decoction on rats hepatic fibrosis[J]. International Journal of Traditional Chinese Medicine, 2010, 32(1): 197-199. DOI: 10.3760/cma.j.issn.1673-4246.2010.03.001
Authors:SHU Jian-chang  DENG Liang  L Xia  HE Ya-jun  ZHU Hai-yan  FU Jing  YE Guo-rong  ZHOU Hai-hua
Affiliation:SHU Jian-chang,DENG Liang,L(U) Xia,HE Ya-jun,ZHU Hai-yan,FU Jing,YE Guo-rong,ZHOU Hai-hua
Abstract:
Keywords:Hepatic fibrosisHuGanJieXian DecoctionPeroxidative damage
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