Determination of drug release in vitro of atractylenolide Ⅰ liposome by RP-HPLC |
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引用本文: | 李志浩,朱雪松,郑芳.Determination of drug release in vitro of atractylenolide Ⅰ liposome by RP-HPLC[J].国际中医中药杂志,2010,32(4):533-534. |
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作者姓名: | 李志浩 朱雪松 郑芳 |
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作者单位: | 湖北省郧阳医学院附属东风医院药剂部,十堰,442008; |
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摘 要: | Objective To establish a RP-HPLC method for the determination of drug release in vitro of atractylenolide Ⅰ liposomes. Methods The release behavior of the drug from liposomes was studied by the third method for dissolution. ZORBAX C18 column (4.6 mm × 250 mm, 5 μm) was used with a mobile phase of Methanol-Acetonitrile-0.2% from liposomes in vitro fitted the log-normal distribution equation and had a property of sustained release. Conclusion The method is simple, fast and selective. It is suitable for the determination of release profile in vitro of atractylenolide Ⅰ liposomes.
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关 键 词: | 白术内酯Ⅰ 脂质体 体外释放度 Atractylenolide Ⅰ |
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