Elevated serum levels of interleukin-18 are associated with insulin resistance in women with polycystic ovary syndrome |
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Authors: | Zhang Yi-fei Yang Yi-sheng Hong Jie Gu Wei-qiong Shen Chun-fang Xu Min Du Peng-fei Li Xiao-ying Ning Guang |
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Institution: | (1) Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University Medical School, 197 Ruijin 2nd Road, 20025 Shanghai, P.R. China |
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Abstract: | Overproduction of proinflammatory factors is associated with obesity and diabetes. Interleukin (IL)-18 as a member of IL-1
cytokine family is increased in obese, in diabetic, and even in polycystic ovary syndrome (PCOS) patients. In the present
study we evaluated the association of serum IL-18 levels with insulin resistance in PCOS women. Forty-two PCOS women and 38
control subjects were enrolled in this study and matched with respect to age and body mass index (BMI). Serum IL-18 levels
and hormones were measured for all subjects. Furthermore, euglycemic hyperinsulinemic clamp test was performed in selected
30 PCOS women and 11 control subjects. Serum IL-18 levels were elevated in PCOS women compared with the control (p=0.003). IL-18 levels were positively correlated with homeostasis model assessment index (HOMA) β index, which assesses β
cell function (p=0.035), but were inversely correlated with clamp indices, which best-represent insulin resistance status: M, Clamp ISIS100,
and MCRg values (p=0.006, 0.010, and 0.009 respectively). No correlation was found between IL-18 and age, BMI, waist-to-hip ratio (WHR), lipid
profile, dehydroepiandrosterone-sulfate (DHEAS), sex hormone-binding globulin (SHBG), or fasting insulin levels. In conclusion,
in the present study, serum IL-18 levels were significantly increased in PCOS women and firmly associated with insulin resistance
displayed by euglycemic hyperinsulinemic clamp test. It indicates that IL-18 may be a contributing factor linking inflammation
and insulin resistance in PCOS women. |
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Keywords: | Interleukin-18 polycystic ovarysyndrome insulin resistance euglycemic hyperinsulinemic clamp test |
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