中医药治疗恶性肿瘤化疗后白细胞降低的研究进展＊

白细胞下降是肿瘤化疗最常见的毒副作用之一,常因此导致化疗终止,影响肿瘤有效治疗。目前临床主要应用集落刺激因子治疗（Colony Stimulating Factor, CSF）,但近年的研究显示CSF具有刺激肿瘤生长风险。中医采用健脾、养血、补肾等方法治疗肿瘤化疗后白细胞降低取得了良好的临床疗效,尤其是近年受到重视的补肾生髓法,不仅可以防治肿瘤化疗白细胞降低,而且具有一定的抑制肿瘤生长的作用,显示出良好的临床优势。本文通过查阅相关文献,对近年来中医治疗肿瘤化疗导致的白细胞降低的有关进展进行了总结分析,为后续研究提供思路。

Review of TCM Treatment of Leukopenia after Chemotherapy for Malignant Tumor

As one of the most common toxic side effects in cancer chemotherapy, leukopenia often leads to termination of chemotherapy, which in turn affects the effective treatment of tumors. At present, colony-stimulating factor therapy (CSF) has been mainly used in clinical practice. However, recent studies have shown that CSF has the risk of stimulating tumor growth. Through the treatment of tumors with the methods of invigorating the spleen, nourishing blood, and tonifying the kidney in traditional Chinese medicine (TMC), leukopenia after chemotherapy has achieved good clinical efficacy. In particular, the method of tonifying the kidney and myelin can not only prevent and treat leukopenia in cancer chemotherapy, but also inhibit tumor growth, which shows good clinical advantages. By reviewing the relevant studies in recent years, this paper aimed to summarize the relevant methods of traditional Chinese medicine in the treatment of leukopenia caused by cancer chemotherapy and provide reference for the future research.