Bioinformatics analysis of breast cancer bone metastasis related gene-CXCR4 |
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| Authors: | Heng-Wei Zhang Xian-Fu Sun Ya-Ning He Jun-Tao Li Xu-Hui Guo Hui Liu |
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| Affiliation: | 1. Department of Breast, Henan Cancer Hospital, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, China |
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| Abstract: | ObjectiveTo analyze breast cancer bone metastasis related gene-CXCR4.MethodsThis research screened breast cancer bone metastasis related genes by high-flux gene chip.ResultsIt was found that the expressions of 396 genes were different including 165 up-regulations and 231 down-regulations. The expression of chemokine receptor CXCR4 was obviously up-regulated in the tissue with breast cancer bone metastasis. Compared with the tissue without bone metastasis, there was significant difference, which indicated that CXCR4 played a vital role in breast cancer bone metastasis.ConclusionsThe bioinformatics analysis of CXCR4 can provide a certain basis for the occurrence and diagnosis of breast cancer bone metastasis, target gene therapy and evaluation of prognosis. |
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| Keywords: | Breast cancer bone metastasis CXCR4 Bioinformatics analysis |
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