Sex- and age-related differences of myocardial perfusion at rest assessed with multidetector computed tomography |
| |
| Authors: | Christina Byrne J Tobias Kühl Mette Zacho Børge G Nordestgaard Andreas Fuchs Daria Frestad Lars Køber Klaus Fuglsang Kofoed |
| |
| Institution: | 1. Department of Cardiology, The Heart Center, Rigshospitalet, University of Copenhagen, 2141, Blegdamsvej 9, 2100-Cph, Denmark;2. Department of Radiology, Rigshospitalet, University of Copenhagen, Denmark;3. Department of Clinical Biochemistry and the Copenhagen General Population Study, Herlev Hospital, University of Copenhagen, Denmark;4. Faculty of Health Sciences, University of Copenhagen, Denmark;1. Departments of Medicine and Imaging and Biomedical Sciences, Cedars-Sinai Heart Institute and Cedars-Sinai Medical Center, 8700 Beverly Boulevard, S. Mark Taper Building Room 1253, Los Angeles, CA 90048, USA;2. Department of Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, USA;3. Department of Diagnostic Radiology, Keio University School of Medicine, Tokyo, Japan;4. Centro Cardiologico Monzino, IRCCS, Milan, Italy;5. Department of Radiology, Yonsei University School of Medicine, Seoul, Korea;6. Department of Medicine, Division of Cardiology, Yonsei University School of Medicine, Seoul, Korea;7. Department of Radiology, Cardiovascular Institute and Fuwai Hospital, Peking Union Medical College, Beijing, China;8. Department of Medicine, Division of Cardiology, Mount Sinai School of Medicine, New York, NY, USA;9. Department of Medicine, Division of Cardiology, University of California at San Diego, San Diego, CA, USA;10. Department of Clinical Radiology, Derriford Hospital, Plymouth, United Kingdom;11. Baptist Hospital of Miami and Baptist Cardiac and Vascular Institute, Miami, FL, USA;12. Walter Reed Medical Center, Bethesda, MD, USA;13. Asan Medical Center, Seoul, Korea;14. St. Paul''s Hospital, Vancouver, British Columbia, Canada;1. Department of Cardiology, Tokyo Women’s Medical University, 8-1 Kawada-cho, Sinjuku-ku, Tokyo 162-8666, Japan;2. Department of Diagnostic Radiology, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka City, Saitama 350-1298, Japan;1. Centre for Sports and Exercise Medicine, Barts and the London School of Medicine and Dentistry, Mile End Hospital, London E1 4DG, UK;2. Pathology Group, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, E1 2ES, UK;1. Department of Medicine, Cardiology Division, Medstar Georgetown University Hospital, 3800 Reservoir Road NW, 5PHC, Washington, DC 20007, USA;2. Siemens Healthcare, Forscheim, Germany;3. Austin Health, Melbourne, Australia;4. Department of Medicine, New York University School of Medicine, 660 First Ave, 2nd Floor, New York, NY 10016, USA;5. Department of Radiology, New York University School of Medicine, New York, NY, USA;1. Radiological Institute, Friedrich-Alexander-University-Erlangen-Nuremberg, Maximiliansplatz 1, 91054 Erlangen, Germany;2. Division of Cardiology, Department of Internal Medicine II, Friedrich-Alexander-University-Erlangen-Nuremberg, Erlangen, Germany;1. Divisions of Cardiology and Cardiac Imaging, St. Paul''s Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada;2. Divisions of Cardiology and Cardiac Imaging Center, Aarhus University Hospital Skejby, Aarhus, Denmark;3. Division of Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA, USA;4. Québec Heart and Lung Institute, Laval University, Québec, QC, Canada |
| |
| Abstract: | BackgroundThe clinical presentation of ischemic heart disease in women differs from men, which could reflect sex-related differences of normal physiology. Cardiac CT angiography provides a noninvasive method to assess both regional and transmural myocardial perfusion in addition to coronary atherosclerosis.ObjectiveThe aim of this study was to evaluate potential sex-related differences of (1) left ventricular (LV) myocardial perfusion measured as LV myocardial attenuation density/LV blood pool attenuation density (MyoAD-ratio) at rest and (2) transmural perfusion ratio (TPR) as a measure of endocardial perfusion relative to epicardial perfusion.MethodsMyocardial perfusion at rest and coronary artery atherosclerosis were evaluated with multidetector CT in 206 asymptomatic women and 203 age-matched men from the Copenhagen General Population Study.ResultsLV myocardial perfusion at rest (LV MyoAD-ratio) was higher in women than in men (9% difference; P = 0.039). In a multivariable analysis, including age, sex, cardiovascular risk factors, Agatston score, and presence of coronary stenosis, global LV MyoAD-ratio remained significantly higher in women than in men (P = 0.045). No effect of cardiovascular risk factors on myocardial perfusion at rest was noted. Myocardial perfusion at rest was correlated to age in men (r = 0.15, P = 0.031) but not in women (r = ?0.01, P = 0.83). TPR was slightly lower in women than in men (1.12 vs 1.14; P = 0.0019).ConclusionLV myocardial perfusion at rest is higher in women than men independent of coronary atherosclerosis in asymptomatic subjects with risk factors. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
