中医经典名方治疗抑郁症的研究进展＊

抑郁症已成为世界上最普遍的公共卫生疾病之一,发病率呈现逐年递增的趋势。大量的流行病学和临床研究证实抑郁症病因复杂,治疗难度大、预后差、致死率高。现有临床治疗抑郁症的方法存在复发率高、疗效滞后、不良反应大等诸多缺陷,因此寻找新的抗抑郁靶向药物是目前面临的重大挑战。中医经典名方具有多靶点、整体调节、协同作用强、安全性高等特点,在抑郁症的临床治疗中展现出良好的疗效和发展前景。本文根据经典名方的功效主治分类,重点阐述经方治疗抑郁症的临床应用,并简要归纳其作用机制,以期为抑郁症的临床诊疗提供参考。

Research Progress on Classic Traditional Chinese Formulas in the Treatment of Depression

Depression has become one of the most common public health diseases in the world, and its incidence is increasing year by year. A large number of epidemiological and clinical studies have confirmed that the causes of depression are complex, difficult to treat, poor prognosis, and high fatality rates. The existing clinical treatment of depression has many defects such as high recurrence rate, lag in efficacy, and large adverse reactions, so finding new antidepressant targeted drugs is a major challenge at present. The classic recipes of traditional Chinese medicine have the characteristics of multi-target, overall regulation, strong synergy and high safety, and show good efficacy and development prospects in the clinical treatment of depression. According to the classification of the efficacy of the classic formula, this paper focused on the clinical application of the classic formula for the treatment of depression, and briefly summarized its mechanism of action, in order to provide a reference for the clinical diagnosis and treatment of depression.