Primo Vessel as a Novel Cancer Cell Migration Path from Testis with Nanoparticle-Labeled and GFP Expressing Cancer Cells |
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| Authors: | Hyun-Jung Han Hong-Bae Kim Jinmyung Cha Jin-Kyu Lee Hyewon Youn June-Key Chung Sungchul Kim Kwang-Sup Soh |
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| Institution: | 1. Nano Primo Research Center, Advanced Institute of Convergence Technology, Seoul National University, Suwon, South Korea;2. Materials Chemistry Laboratory, Department of Chemistry, Seoul National University, Seoul, South Korea;3. Cancer Imaging Center, Seoul National University Cancer Hospital, Seoul, South Korea;4. Department of Nuclear Medicine, College of Medicine, Seoul National University, Seoul, South Korea;5. Department of Acupuncture and Moxibustion, Wonkwang University Hospital, Gwangju, South Korea |
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| Abstract: | Background/aimRecently, a novel circulatory system, the primo vascular system (PVS), was found to be a potent metastatic route of cancer cells. The aim of the current work is to demonstrate that cancer cells injected into the testis migrate through the primo vessel (PV).Materials and methodsNCI-H460 cells labeled with fluorescent nanoparticles (FNP) or green fluorescent protein (GFP) gene transfection were injected into testicular parenchyma in 24 rats. After 24 hours of injection, the abdominal cavity was investigated via a stereomicroscope, to detect the PVS, and the samples were analyzed histologically with 4′,6-diamidino-2-phenylindole (DAPI) and hematoxylin and eosin.ResultsInjected cancer cells were detected inside the PVS distributed on the abdominal organs. Some were detected inside intestinal parenchyma into which the attached primo vessels (PVs) entered.ConclusionThe results supported the fact that the PVS may be a novel migration path of cancer cells, in addition to the lymphatic and hematogenous routes. |
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| Keywords: | cancer metastasis migration nanoparticle primo vascular system testis |
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