Serum brain-derived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodes |
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| Authors: | Angelo BM Cunha Benicio N Frey Ana C Andreazza Júlia D Goi Adriane R Rosa Carlos A Gonçalves Aida Santin Flavio Kapczinski |
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| Institution: | 1. Department of Neuropsychiatry, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Faixa de Camobi Km 9, 97105 900 Santa Maria, RS, Brazil;2. Department of Biochemistry, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600/Anexo, 90035 003 Porto Alegre, RS, Brazil;3. Bipolar Disorders Program, Centro de Pesquisas, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, 2350, 90035 003 Porto Alegre, RS, Brazil |
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| Abstract: | Genetic and pharmacological studies have suggested that brain-derived neurotrophic factor (BDNF) may be associated with the pathophysiology of bipolar disorder (BD). The present study investigated serum BDNF levels in manic, depressed, euthymic BD patients and in matched healthy controls, using an enzyme-linked immunosorbent assay (sandwich-ELISA). Serum BDNF levels were decreased in manic (p = 0.019) and depressed (p = 0.027) BD patients, as compared with euthymic patients and controls. Serum BDNF levels were negatively correlated with the severity of manic (r = −0.37, p = 0.005) and depressive (r = −0.30, p = 0.033) symptoms. These findings further support the hypothesis that the BDNF signaling system may play a role in the pathophysiology of BD. |
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| Keywords: | Bipolar disorder Brain-derived neurotrophic factor Depression Mania Mood stabilizers Pathophysiology |
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