Increased serum glial cell line-derived neurotrophic factor immunocontent during manic and depressive episodes in individuals with bipolar disorder |
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Authors: | Adriane R. Rosa,Bení cio N. Frey,Ana C. Andreazza,Keila M. Ceresé r,Angelo B.M. Cunha,Joã o Quevedo,Aida Santin,Carmem Gottfried,Carlos A. Gonç alves,Eduard Vieta,Flá vio Kapczinski |
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Affiliation: | 1. Bipolar Disorders Program, Centro de Pesquisas, Hospital de Clínicas de Porto Alegre, Ramiro Barcelos 2350, Zip code: 90035-003, Porto Alegre, RS, Brazil;2. Bipolar Disorders Program, Clinical Institute of Neuroscience, Hospital Clinic de Barcelona, Villarroel 170, Barcelona 08036, Spain;3. Department of Biochemistry, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos, 2600-Anexo, Zip code: 90035-003, Porto Alegre, RS, Brazil;4. Department of Neuropsychiatry, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Faixa de Camobi Km 9. Zip code: 97105-900, Santa Maria, RS, Brazil;5. Laboratory of Neurotoxicology, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, Zip code: 88806-000, Criciúma, SC, Brazil |
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Abstract: | Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor from the transforming growth factor β family, which plays a role in the development and function of hippocampal cells. Preclinical studies suggest that changes in neurotrophic growth factor systems might be involved in the pathophysiology of mood disorders including bipolar disorder (BD) [E.J. Nestler, M. Barrot, R.J. DiLeone, A.J. Eisch, S.J. Gold, L.M. Monteggia, Neurobiology of depression, Neuron 34 (2002) 13–25]. This is the first study to analyze GDNF immunocontent in BD subjects across different mood states, including mania, depression, and remission (euthymia). Fourty-four bipolar patients (14 depressed, 15 manic, and 15 euthymic) and 14 healthy controls, diagnosed according to the Structural Clinical Interview for DSM-IV were studied. Serum GDNF immunocontent was measured using Western blotting. Serum GDNF immunocontent was increased in manic (F = 42.31; p = 0.001; one-way ANOVA) and depressed (F = 42.31; p = 0.004; one-way ANOVA) bipolar patients, but not in euthymic patients as compared with controls. Our results indicate that changes in GDNF immunocontent occur during acute major affective episodes in bipolar subjects. These results further support the role of neurotrophins in the pathophysiology of bipolar disorder. Whether the observed increase in GDNF immunocontent correspond to a pathological or an adaptive response remains to be determined. |
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Keywords: | Bipolar disorder Glial cell line-derived neurotrophic factor Pathophysiology Western blotting |
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