IL-6 trans-signaling: the heat is on |
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| Authors: | Rose-John Stefan Neurath Markus F |
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| Affiliation: | Department of Biochemistry, Christian-Albrechts-Universit?t zu Kiel, Olshausenstrasse 40, D-24098, Kiel, Germany. |
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| Abstract: | The molecular consequence of the fever response has been illuminated by a recent study showing that a temperature shift to 40 degrees C resulted in increased leukocyte adhesion to tissue sections, which was mediated by L-selectin activation in lymphocytes. This L-selectin activation during heat responses was dependent on IL-6 trans-signaling via the soluble IL-6R. |
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